Journal of Pharmacokinetics and Biopharmaceutics

, Volume 17, Issue 5, pp 593–599 | Cite as

Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs

  • Nobutoshi Watari
  • Leslie Z. Benet


A general treatment for determination of mean residence time (MRTV)and steady-state volume of distribution (V ss )after multiple drug inputs via any mode of administration is presented. For multiple inputs, either simultaneous or consecutive, the mean input time (MIT)can be readily calculated using the general equations presented here. Sample calculations for (MIT, MRT),and V ss following different combinations of multiple drug inputs are presented. Errors inherent in noncompartmental area determinations are discussed.

Key words

mean input time steady-state volume of distribution mean residence time multiple dosing input noncompartmental model 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Nobutoshi Watari
    • 1
  • Leslie Z. Benet
    • 1
  1. 1.Department of Pharmac, School of PharmacyUniversity of CaliforniaSan Francisco

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