Abstract
Many features of celiac disease resemble those of intestinal sucrase-isomaltase deficiency, a recognized inborn error of metabolism. Both diseases usually present in the first few years of life, have a high familial incidence, and involve intolerance to a specific foodstuff which tends to diminish in later childhood. It is proposed that celiac disease is an inborn error of metabolism involving deficiency of an intestinal peptidase. This allows a number of aspects of celiac disease to be explained and certain predictions to be made about the disorder.
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Townley, R.R.W. Celiac disease—An inborn error of metabolism. Digest Dis Sci 18, 797–800 (1973). https://doi.org/10.1007/BF01070850
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DOI: https://doi.org/10.1007/BF01070850