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Effect of intragastric infusion of tobacco powder on DNA content of gastric aspirate

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Abstract

The DNA content in gastric aspirate was measured before and during intragastric infusion of 0.1 or 0.2 g/hr tobacco powder. The infusion of 0.1 g/hr caused an insignificant rise in the DNA content but infusion of 0.2 g/hr of tobacco caused a marked and rapid rise in the DNA content of gastric aspirate during the hour of infusion. The effect of tobacco was transient (ie, only during the period of infusion). These observations indicate that the increased exfoliation of surface epithelial cells of human gastric mucosa with tobacco infusion is dose related.

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Authors and Affiliations

  1. Pai Department of Gastroenterology, B.Y.L. Nair Charitable Hospital, Dr. A.L. Nair Road, 400 008, Bombay, India

    H. G. Desai PhD, MD, K. Venugopalan BSc & F. P. Antia MS, MD, FRCP

Authors
  1. H. G. Desai PhD, MD
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  2. K. Venugopalan BSc
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  3. F. P. Antia MS, MD, FRCP
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Additional information

This work was supported by a grant from B.Y.L. Nair Charitable Hospital and T.N. Medical College Research Society.

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Desai, H.G., Venugopalan, K. & Antia, F.P. Effect of intragastric infusion of tobacco powder on DNA content of gastric aspirate. Digest Dis Sci 20, 450–453 (1975). https://doi.org/10.1007/BF01070790

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