The American Journal of Digestive Diseases

, Volume 20, Issue 3, pp 262–273 | Cite as

The influence of food consumption and running activity on the activity-stress ulcer in the rat

  • William P. Paré
Original Articles

Abstract

Rats housed in activity cages and fed 1 hour daily died before the end of the 21-day experimental period and revealed extensive ulcers in the glandular stomach, whereas food-yoked control rats, not housed in activity cages, did not die and were ulcer-free. Rats demonstrating high running-activity levels underad lib feeding conditions subsequently revealed a higher incidence of lesions as compared to low-activity rats. Attempts to attenuate activity and lesion incidence by reversing the light-dark cycle failed, but the higher mortality level in rats under the reversed light-dark condition was related to higher activity levels in these rats. Young rats with high activity levels died sooner and had ulcers when compared to older rats with low activity levels. These results suggested that running activity, and not reduced food intake, was critically involved in the development of the activity-stress ulcer.

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References

  1. 1.
    Routtenberg A, Kuznesov AW: Self-starvation of rats living in activity wheels on a restricted feeding schedule. J Comp Physiol Psychol 64:414–421, 1967Google Scholar
  2. 2.
    Routtenberg A: “Self-starvation” of rats living in activity wheels: Adaptation effects. J Comp Physiol Psychol 66:234–238, 1968Google Scholar
  3. 3.
    Barboriak JJ, Knoblock HW Jr: Gastric lesions in food-restricted young rats. Proc Soc Exp Biol Med 141:830–832, 1972Google Scholar
  4. 4.
    Spatz C, Jones SD: Starvation anorexia as an explanation of “self-starvation” of rats living in activity wheels. J Comp Physiol Psychol 77:313–317, 1971Google Scholar
  5. 5.
    Strutt GF, Stewart CN: The role of blood glucose in activity-related self-starvation. Psychon Sci 18:287–289, 1970Google Scholar
  6. 6.
    Paré WP, Houser VP: Activity and food-restriction effects on gastric glandular lesions in the rat: The activity-stress ulcer. Bull Psychon Soc 2:213–214, 1973Google Scholar
  7. 7.
    Brodie DA: Stress ulcer as an experimental model of peptic ulcer disease. Peptic Ulcer, CJ Pfeiffer (ed). Philadelphia, Lippincott, 1971, p 71Google Scholar
  8. 8.
    Ogawa T, Chiles T, Necheles H: Starvation ulcer in the mouse. Am J Physiol 198:619–620, 1960Google Scholar
  9. 9.
    Paré WP, Temple LJ: Food deprivation, shock stress and stomach lesions in the rat. Physiol Behav 11:371–375, 1973Google Scholar
  10. 10.
    Pfeiffer CJ: Gastrointestinal response to malnutrition and starvation. Postgrad Med 47:110–115, 1970Google Scholar
  11. 11.
    Richter CP: Biological Clocks in Medicine and Psychiatry. Springfield, Illinois, Charles C Thomas, 1965, pp 7–25Google Scholar
  12. 12.
    Bolles RC, Stokes LW: Rat's anticipation of diurnal and a-diurnal feeding. J Comp Physiol Psychol 60:290–294, 1965Google Scholar
  13. 13.
    Reid LS, Finger FW: The rat's adjustment to 23-hour food-deprivation cycles. J Comp Physiol Psychol 48:110–113, 1955Google Scholar
  14. 14.
    Richter CP: Animal behavior and internal drives. Q Rev Biol 2:307–343, 1927Google Scholar
  15. 15.
    Jones DC, Kimeldorf DO, Rubadeau DO, Castanera TJ: Relationship between volitional activity and age in the male rat. Am J Physiol 172:109–114, 1953Google Scholar
  16. 16.
    Richter CP: A behavioristic study of the activity of the rat. Comp Psychol Monogr 1:2, 1922Google Scholar
  17. 17.
    Smith LC, Dugal LP: Age and spontaneous running activity of male rats. Can J Physiol Pharmacol 43:852–856, 1965Google Scholar
  18. 18.
    Hunt JMc, Schlosberg H: The influence of illumination upon general activity in normal, blinded and castrated male white rats. J Comp Psychol 28:285–298, 1939Google Scholar
  19. 19.
    Winer BJ: Statistical Principles in Experimental Design. New York: McGraw Hill, 1962Google Scholar
  20. 20.
    Jakubczak LF: Age differences on the effect of terminal food deprivation (starvation) on activity, weight loss, and survival of rats. J Gerontol 22:421–426, 1967Google Scholar
  21. 21.
    Hodge MH, Peacock LJ, Hoff LA: The effect of age and food deprivation upon general activity of the rat. J Genet Psychol 111:135–145, 1967Google Scholar
  22. 22.
    Pfeiffer CJ, Debro FR, Muller PJ: Gastric pathologic and biochemical changes induced by starvation of weanling rats. Life Sci 5:509–519, 1966Google Scholar
  23. 23.
    Mikhail AA: Stress and ulceration in the glandular and nonglandular portions of the rat's stomach. J Comp Physiol Psychol 85:636–642, 1973Google Scholar
  24. 24.
    Peters JM: Effects of absolute starvation and refeeding on organ weights and water contents of albino rats. Growth 31:191–203, 1967Google Scholar
  25. 25.
    Peters JM, Boyd EM: Organ weights and water contents during acute starvation, thirst and stress. Growth 32:283–296, 1968Google Scholar
  26. 26.
    Peiers JM, Boyd EM: Organ weights and water levels of the rat following reduced food intake. J Nutr 90:354–360, 1966Google Scholar
  27. 27.
    Noble RL, Collip JB: A quantitative method for the production of experimental traumatic shock without haemorrage in unanesthetized animals. Q J Exp Physiol 31:187–199, 1942Google Scholar
  28. 28.
    Frenkl R, Csalay L, Makara G: The effect of regular muscular activity on gastric acid secretion and on the development of experimental ulcer in the albino rat. Acta Physiol 22:203–208, 1962Google Scholar
  29. 29.
    Levrat M, Lambert R: Experimental ulcers produced in rats by modification of environment. Gastroenterology 37:421–426, 1959Google Scholar
  30. 30.
    Senay EC, Levine RJ: Synergism between cold and restraint for rapid production of stress ulcers in rats. Proc Soc Exp Biol Med 124:1221–1228, 1967Google Scholar
  31. 31.
    Ader R: Susceptibility to gastric lesions in the rat. J Neuropsychiat 4:399–408, 1963Google Scholar
  32. 32.
    Paré WP: Conflict duration, feeding schedule, and strain differences in conflict-induced gastric ulcers. Physiol Behav 8:165–171, 1972Google Scholar
  33. 33.
    Sawrey WL, Weisz JD: An experimental method of producing gastric ulcers. J Comp Physiol Psychol 49:269–270, 1956Google Scholar
  34. 34.
    Weiss JM: Effects of punishing the coping response (conflict) on stress pathology in rats. J Comp Physiol Psychol 77:14–21, 1971Google Scholar
  35. 35.
    Weisz JD: The etiology of experimental gastric ulceration. Psychosom Med 19:61–73, 1957Google Scholar
  36. 36.
    Caul WF, Buchanan DC, Hays RC: Effects of unpredictability of shock on incidence of gastric lesions and heart rate in immobilized rats. Physiol Behav 8:669–672, 1972Google Scholar
  37. 37.
    Gliner JA, Shemberg KM: Conditioned fear and gastric pathology in a continuing stress-rest paradigm in rats. J Comp Physiol Psychol 74:20–22, 1971Google Scholar
  38. 38.
    Price KP: Predictable and unpredictable shock: Their pathological effects on restrained and unrestrained rats. Psychol Rep 30:419–426, 1972Google Scholar
  39. 39.
    Weiss JM: Somatic effects of predictable and unpredictable shock. Psychosom Med 32:397–408, 1970Google Scholar
  40. 40.
    Brodie DA, Hanson HM: A study of the factors involved in the production of gastric ulcers by the restraint technique. Gastroenterology 38:353–360, 1960Google Scholar
  41. 41.
    Mikhail AA, Holland HC: A simplified method of inducing stomach ulcers. J Psychosom Res 9:343–347, 1966Google Scholar
  42. 42.
    Rossi G, Bonfils S, Lieffoogh F, Lambling A: Technique nouvelle pour produire des ulcérations gastriques chez le rat blanc: l'ulcére de contrainte. Compt Rend Soc Biol 150:2124, 1956Google Scholar
  43. 43.
    Bonfils S, Lieffoogh G, Rossi G, Lambling A: L'ulcere de contrainte du rat blanc. Modifications de la fréquence léssionnelle par différents procédés opératoires et pharmacodynamiques. Compt Rend Soc Biol 151:1149, 1957Google Scholar

Copyright information

© Digestive Disease Systems, Inc. 1975

Authors and Affiliations

  • William P. Paré
    • 1
  1. 1.Pavlovian Research LaboratoryVeterans Administration HospitalPerry Point

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