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Divergent responses to long-term stressors in rat lines selected for different functional states of the nervous system

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Abstract

The conditioned and reflex parameters in rat lines selected for the threshold of excitability (a fundamental characteristics of the functional state of the nervous system) were estimated. This measure is based on the response of the tibial nerve to electrical stimulation, which gives a general indication of the level of excitability of other parts of the nervous system. Testing was made 1–3 days after 15 days of daily stress caused by randomly presented pairing of light and unavoidable electric shock. Expression of the sensitivity to the electric current, and the reflex components of the behavior, depends on the genetically determined level of the functional state of the nervous system

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References

  • Airpetyanz, M. G., and Vein, A. M. (1982).Neuroses in the Laboratory and Clinic, Science Press, Moskow (Russian).

    Google Scholar 

  • Alexandrova, N. P., Shiryaeva, N. V., Kratin, Yu. G., and Lopatina, N. G. (1981). The activation threshold in the brains of rats selected on the excitability of nervous-muscle apparatus.Proc. Acad. Sci. USSR 259:1233–1235 (Russian).

    Google Scholar 

  • Beck, C. H., and Chow, H. L. (1984). Solitary and social behavior of male rats in the open-field.Physiol. Behav. 32:941–951.

    Google Scholar 

  • Bekhtereva, N. P. (1988).Healthy and Diseased Human Brain, Science Press, Moskow (Russian).

    Google Scholar 

  • Benzer, S. (1971). From the gene to behavior.JAMA 218:1015–1022.

    Google Scholar 

  • Blok, V. (1970). In Fress, P., and Piaje, J. (eds.),Levels of Vigilance and Attention, Experimental Psychology Progress Press, Moscow (Russian).

    Google Scholar 

  • Dilman, V. M. (1987).Four Models of Medicine, Meditsin Press, Leningrad (Russian).

    Google Scholar 

  • Dmitriev, Yu. S., (1981). Localization of genes which are responsible for line differences on thresholds neuromuscular excitability of mouse.Proc. Acad. Sci. USSR 261:203–206 (Russian).

    Google Scholar 

  • Dmitriev, Yu. S., and Vaydo, A. I. (1981a). Study of some parameters of functional state of the nervous system and pecularities of behavior in connection with its inheritance in inbred mouse strains. 1. The analysis of inheritance of the nervous-muscle apparatus in inbred mouse strains.Genetica (Moskow) 2:282–290 (Russian).

    Google Scholar 

  • Dmitriev, Yu. S., and Vaydo, A. I. (1981b). Study of some parameters of functional state of the nervous system and pecularities of behavior in connection with its inheritance in inbred mouse strains. 2. The correlation of the threshold of the nerve-muscle excitability with some behavioral traits of mice.Genetica (Moskow) 2:291–296 (Russian).

    Google Scholar 

  • Fedorov, V. K., and Sitdicov, M. X. (1974). Automatic device for elaboration and recording conditioned reflexes in small laboratory animals.J. High. Nerv. Act.,2:434–439 (Russian).

    Google Scholar 

  • Fedorov, V. K., Sitdicov, M. X., and Shiryaeva, N. V. (1972). Passive avoidance conditioning in rats.J. High. Nerv. Act. 3:624–627 (Russian).

    Google Scholar 

  • File, S. E., and Hyde, S. R. H. (1979). A test of anxiety that distinguishes between actions of benzidiazepines and those of other minor tranquilisers and of stimulants.Pharm. Biochem. Behav. 11:65–69.

    Google Scholar 

  • Goffman, M. A., Vaydo, A. I., and Shiryaeva, N. V. (1987). Morpho-functional pecularities of the thyroid of rats selected by nervous system excitability.Endocrinol. Problems Moskow 4:57–59 (Russian).

    Google Scholar 

  • Hecht, K., Treptov, K., Choinowski, S., and Peschel, M. (1972).Die raumzeitliche Organization der Reiz-Reactions-Beziehungen bedingtreflectorisher Prozesse, S. Fisher, Jena, p. 103.

    Google Scholar 

  • Hutchinson, R. R., Ulrich, R. E., and Asrin, N. H. (1965). Effects of age and related factors on the pain-aggression reaction.J. Comp. Physiol. Psychol. 3:365–369.

    Google Scholar 

  • Kolpakov, V. G., Ruzner, M. S., Kornetov, N. A., Samochvalov, T. V., Zalevsky, G. B., and Korolenko, F. P. (1985).Genetic and Evolutionary Problems of Psychiatry, Science Press, Novosibirsk (Russian).

    Google Scholar 

  • Kotlyar, B. I. (1987). Neurophysiological bases of aspects of the memory: system. In Vartanyan, G. A., and Kruglikov, R. I. (eds.),Mechanisms of Memory, Science Press, Leningrad (Russian).

    Google Scholar 

  • Krushinsky, L. V. (1946). The role of the heredity and the training in the showing and the expressing of the behavior properties in dogs.News Acad. Sci. USSR 1:69–81.

    Google Scholar 

  • Lat, J. (1965). The spontaneous exploratory reactions as a tool for psychoparmacological studies. A contribution towards a theory of contradictory results in psychopharmacology. In Michelson, M. Ya., Longo, V. G., and Votova, L. (eds.),Pharmacology of Conditioning, Learning and Retention, Proc. 1 Int. Pharm. Meet. Czechoslovak. Med. Press, Praha.

    Google Scholar 

  • Lopatina, N. G. (1987). The investigation of genetic bases the higher nervous activity. In Batuev, A. S. (ed.),Physiology of Behavior: Neurobiological Objective Laws, Science Press, Leningrad (Russian).

    Google Scholar 

  • Lopatina, N. G., Shiryaeva, N. V., Vaido, A. I., and Kulagin, D. A. (1988). Stress reactivity of threats which are characterized different level of the nervous system excitability.Proc. Int. Meet: Ontogen. Gene-Evol. Aspects Neuroendrocrinol. Regulat. Stress, Novosibirsk, pp. 94–95.

  • Manning, A. (1979).An Introduction to Animal Behavior, Edward Arnold, London.

    Google Scholar 

  • Pavlov, I. P. (1951).Lecture About the Activity of the Cerebral Hemispheres. The Complete Works, Moscow, Vol 4 (Russian).

  • Savvateeva, E. V. (1976). Analysis of the inheritance of neuromuscular excitability parameters in diallel crosses of four Drosophilia melanogaster strains.Genet. Moskow 12:95–104 (Russian).

    Google Scholar 

  • Sharagina, L. M., Savvateeva, E. V., Peresleni, A. G., Shiryaeva, N. V., and Vaydo, A. I. (1989). Neurotization influence of PDE activity cycle nucleotides and calmodullin in parts of the brain of rats, selected by threshold of excitability.Proc. Mediat. Horm., Susdal, 218(russ).

  • Sokolov, E. N. (1975). Introduction. In Sokolov, E. N., Danilova, E. D., and Homskya, E. D. (eds.),Functional States of Brain, Moscow University Press, Moscow (Russian).

    Google Scholar 

  • Taranova, N. P., Klennikova, V. A., Vaydo, A. I., Shiryaeva, N. V., Kulagin, D. A., and Lopatina, N. G. (1990). The influence of sleep deprivation on the ATPs activity of hippocampus neurones of rats selected by excitability.Neurochemistry, in press (Russian).

  • Vaydo, A. I., and Sitdicov, M. X. (1979). Selection of rat strains by long-term threshold of excitability of neuromuscular apparatusGenetica Moscow 1:144–148.

    Google Scholar 

  • Vaydo, A. I., Enin, L. D., and Shiryaeva, N. V. (1985). Spike conduction velocity in caudal and tibial nerves of lines selected for excitability of the nervous-muscleapparatus.Genetica Moskow 2:262–264(Russian).

    Google Scholar 

  • Vaydo, A. I., Shiryaeva, N. V., and Rakizkya, V. V. (1988). Content of catecholamines and second messengers in brain of rats selected by functional state of nervous system.Proc. Mediat. Behav., Novosibirsk, pp. 15–16 (Russian).

  • Vaydo, A. I., Lopatina, N. G., Shiryaeva, N. V., and Kulagin, D. A. (1989). Genetic control of the nervous system tonicity and its role in normal and patological activity of the brain.Proceedings, Third Genetics and Selective Breeding Seminar, News of Siberian Department of Academy of Science USSR, Novosibirsk, Vol. 2, p. 19.

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Vaydo, A.I., Shiryaeva, N.V. & Lopatina, N.G. Divergent responses to long-term stressors in rat lines selected for different functional states of the nervous system. Behav Genet 23, 499–503 (1993). https://doi.org/10.1007/BF01067986

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