Abstract
Female mice from inbred strains carrying a Robertsonian translocation (nine CBARb and eight C57BL/6Rb) were compared with animals from their respective strains (seven CBA and nine C57BL/6) first in open-field activity (two exposures of 10-min duration), then during 5 days (with six trials each) in Morris' swimming navigation test, and finally, in their ability to extrapolate the future position of a food reward being moved slowly out of their reach. ANOVA (strain and translocation) revealed significant effects of Robertsonian translocations (Rb) in swimming navigation,Rb mice being impaired primarily in the initial phases of acquisition and during the first trials of platform reversal and the impairment being stronger in C57BL/6 mice. In the open field,Rb mice were as active as the normal strains but showed significantly increased path tortuosity and moved slightly faster. In the extrapolation task,Rb mice showed above-chance levels in moving to the target indicated by the disappearance of the stimulus, while normal mice chose at chance levels, but the translocation effects were not statistically significant. These data indicate that telocentric fusion of chromosomes may entail behavioral alterations, perhaps by subtle changes in neurotransmitters or limbic circuitry. The expression of such alterations, however, can be remarkably strain dependent.
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References
Baranov, V. S., and Dyban, A. P. (1971). New marker Robertsonian translocation (autosomal central fusion) in laboratory mice.Tsytologia 7:820–826.
Baranov, V. S. (1980). Mice with Robertsonian translocations in experimental biology and medicine.Genetica 52/53:23–36.
Bernasconi-Guastalla, S., Wolfer, D. P., and Lipp, H.-P. (1994). Hippocampal mossy fibers and swimming navigation in mice: Correlations with size and left-right asymmetries.Hippocampus (in press).
Billia, F., Baskys, A., Carlen, P. L., and De Boni, U. (1993). Rearrangement of centromeric satellite DNA in hippocampal neurons exhibiting long-term potentiation.Mol. Brain Res. 14:101–108.
Bonhomme, F. (1992). Genetic diversity and evolution in the genusMus.. In Goldowitz, D., Wahlsten, D., and Wimer, R. E. (eds.),Techniques for the Genetic Analysis of Brain and Behavior: Focus on the Mouse, Elsevier, Amsterdam, pp. 41–56.
Britton-Davidian, J., Nadeau, J. H., Croset, H., and Thaler, L. (1989). Genic differentiation and origin of Robertsonian populations of the house mouse (Mus musculus domesticus Rutty).Genet. Res. 53:29–44.
Büeler, H., Fischer, M., Lang, Y., Blüthmann, H., Lipp, H.-P., DeArmond, S. J., Prusiner, S. B., Aguet, M., and Weissmann, C. (1992). The neuronal cell surface protein PrP is not essential for normal development and behavior of the mouse.Nature 356:577–582.
Capanna, E. (1982). Robertsonian numerical variation in animal speciation: Mus musculus, and emblematic model.Prog. Clin. Biol. Res. 96:155–177.
Dell'Omo, G., Wolfer, D., Alleva, E., and Lipp, H.-P. (1993). Impaired acquisition of swimming navigation in adult mice exposed prenatally to oxazepam.Psychopharmacology (Berl.) 111:33–38.
Dyban, A. P., and Baranov, V. S. (1987).Cytogenetics of Mammalian Development, Clarendon Press, Oxford.
Grant, S. G., O'Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P., and Kandel, E. R. (1992). Impaired long-term potentiation, spatial learning, and hippocampal development infyn mutant mice.Science 258:1903–1910.
Gropp, A., Winking, H., Zech, L., and Müller, H. (1972). Robertsonian chromosomal variation and identification of metacentric chromosomes in feral mice.Chromosoma 39: 265–288.
Jotterand, M. (1992). The role of chromosomal polymorphism in speciation.Caryologia 28:335–340.
Kramnik, J. B., Moisseeva, E. V., and Slationova, S. V. (1989). Characteristics and testing of two mouse strains with chromosomal markers.Mouse Newslett. 85:10.
Krushinskii, L. V. (1991).Biological Basis of Animal Reasoning. Physiological and Evolutionary Approaches, Ed. 2, Oxonian Press, New Delhi/Calcutta.
Krushinskii, L. V., Astaurova, N. B., Kouznetzova, L. M., Otchinskaya, E. I., Poletaeva, L. I., Romanova, L. G., and Sotskaya, M. N. (1975). The role of genetic factors in determining the extrapolation ability in animals. In Fedorov, V. K., and Ponomarenko, V. V. (eds.),Current Problems in Behavioral Genetics, Nauka, Leningrad, pp. 98–110.
Krushinskii, L. V., Poletaeva, I. I., Romanova, L. G., Dyban, A. P., Bananov, V. S., and Popova, N. V. (1978). The perspectives of physiological and genetic investigation of extrapolation ability in mice.Zh. Vyssh. Nerv. Deiat. 28:903–912.
Krushinskii, L. V., Dyban, A. P., Baranov, V. S., Poletaeva, I. I., and Romanova, L. G. (1982). Features of higher nervous activity in mice with Robertsonian chromosomal translocations (Osobennosti vysshei nervnoi deiatel'nosti myshei s robertsonovskimi translokatsiiami khromosom).Zh. Vyssh. Nerv. Deiat. 32:446–454.
Krushinskii, L. V., Dyban, A. P., Baranov, V. S., Poletaeva, I. I., Romanova, L. G., and Udalova, L. D. (1986). Behavior of mice with robertsonian translocations of chromosomes (Povedenie myshei s robertsonovskimi translokatsiiami khromosom).Genetika 22:434–441.
Lehmann, E., and Radbruch, A. (1977). Robertsonian translocations inMus musculus from Sicily.Experientia 33:1025–1026.
Lipp, H.-P., Schwegler, H., Heimrich, B., and Driscoll, P. (1988). Infrapyramidal mossy fibers and two-way avoidance learning: Developmental modification of hippocampal circuitry and adult behavior of rats and mice.J. Neurosci. 8:1905–1921.
Lipp, H.-P., Büchel, C., Wolfer, D. P., and Scheffrahn, H. (1991). Variations in size of corpus callosum, eye color and hippocampal mossy fibers: Their relations to swimming navigation learning of mice.Third IBRO World Congress of Neuroscience Abstracts p. 169.
Lipp, H.-P., Wolfer, D. P., Bozizevic, M., Carmeliet, P., Collen, D., and Mulligan, R. M. (1993). Swimming navigation learning in mice deficient for tissue plasminogen activator: Impaired acquisition but intact spatial memory.Soc. Neurosci. Abstr. 19:799.
Morris, R. G. M. (1984). Development of a water-maze procedure for studying spatial learning in the rat.J. Neurosci. Methods,11:47–60.
Patton, J. L., and Sherwood, S. W. (1982). Genome evolution in pocket gophers (genus Thomomys). I. Heterochromatin variation and speciation potentialChromosoma 85:149–162.
Poletaeva, I. I., Tretiak, T. M., and Smirnova, G. V. (1989). Study of noradrenaline and serotonin levels in mice with behavioral differences.Zh. Vyssh. Nerv. Deiat. 39:76–80.
Ricceri, L., Waanders, R., Wolfer, D. P., and Lipp, H.-P. (1993). Open-field locomotion and circling behavior in mice with missing or variably sized corpus callosum (submitted for publication).
Schöpke, R., Wolfer, D. P., Lipp, H.-P., and Leisinger-Trigona, M.-C. (1991). Swimming navigation and stuctural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse.Hippocampus 1:315–328.
Schwegler, H., Crusio, W. E., Lipp, H.-P., Brust, I., and Mueller, G. G. (1991). Early postnatal hyperthyroidism alters hippocampal circuitry and improves radial maze learning in adult mice.J. Neurosci. 11:2102–2106.
Scriven, P. N. (1992). Robertsonian translocations introduced into an island population of house mice.J. Zool.,227:493–502.
Viroux, M.-C., and Bauchau, V. (1992). Segregation and fertility inMus musculus domesticus (wild mice) heterozygous for the Rb(4.12) translocation.Heredity (Edinburgh) 68:131–134.
Ward, R., Tremblay, L., and Lassonde, M. C., (1987). The relationship between callosal variation and lateralization in mice is genotype-dependent.Brain Res. 424:84–88.
White, M. J. D. (1975). Chromosome repatterning — regularities and restrictions.Genetics 79(Suppl.2):63–72.
Wolfer, D. P., and Lipp, H.-P. (1992). A computer program for detailed off-line analysis of Morris water maze behavior.J. Neurosci. Meth. 41:65–74.
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Leitinger, B., Poletaeva, I.I., Wolfer, D.P. et al. Swimming navigation, open-field activity, and extrapolation behavior of two inbred mouse strains with Robertsonian translocation of chromosomes 8 and 17. Behav Genet 24, 273–284 (1994). https://doi.org/10.1007/BF01067194
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DOI: https://doi.org/10.1007/BF01067194