Abstract
Newborn female mice of the C57BL/6J and BALB/cJ inbred strains and their reciprocal F1 hybrids were injected either with testosterone or with oil vehicle alone. Both the repeatability and mean level of open-field activity scores over a 10-day test period increased in hormone-injected animals compared with controls. Increased activity due to hormonal treatment was greater in hybrid females than in inbred females. There was no consistent effect of hormonal treatment on open-field defecation.
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This work was supported in part by NINDS RCD 70099.
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Hegmann, J.P., Blakley, A. Neonatal androgen injection changes open-field behavior of mice. Behav Genet 7, 23–27 (1977). https://doi.org/10.1007/BF01067173
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DOI: https://doi.org/10.1007/BF01067173