Summary
With a newly developed quadrupole mass spectrometer several blood gas partial pressures are recorded simultaneously and continuously. In the mass filter the separation of the ions to be detected takes place in a hyperbolic electric field with variable direct and alternating voltages with a constant frequency of 2.4 MHz.
For blood gas analysis a fully relaxed experimental animal was artificially ventilated and provided with arterial and venous catheters. Each catheter consisted flexible steel tubing (external diameter 0.6 mm) slotted near the end and covered with a silicone rubber membrane. The distance from the measuring tip to the mass spectrometer was 150 cm. Experiments with blood, in vivo equilibrated with gas mixtures, showed good reproducibility; the mean error of the helium partial pressure, for example, was less than 4%.
During respiration using a gas mixture with 40% argon, the time constantt 63% was found to be 55 s for the whole experimental arrangement including the experimental animal.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Albrecht, H., Schaldach, M.: Ramanspektrometrische Gas-Partialdruckbestimmung für eine kontinuierliche Überwachung der Blut- und Atemgase. Biomed. Techn.20 (Ergzbd.), 119–120 (1975)
Anlinger, F., Franke, G., Habfast, K., Kienitz, H., Spiteller, G.: Massenspektrometrie (H. Kienitz, ed.). Weinheim: Verlag Chemic 1968
Becker, H., Behrens, D., Hellige, D., Hensel, I., Kettler, D., Martel, J., Bretschneider, H. J.: Messung der Organdurchblutung mit Helium durch massenspektrometrischen Nachweis. Verh. dtsch. Ges. Kreisl.-Forsch.39, 263–267 (1973)
Beste, K.-W.: Diffusionsprozesse an künstlichen Membranen und massenspektrometrischer Nachweis. Biomed. Techn.19, 234–239 (1974)
Beste, K.-W., Hellige, G., Hensel, I., Schenk, H.-D., Bretschneider, H. J.: Messung von Blutgaspartialdrucken in vivo mit einer Massenspektrometer-Sonde im blutdurchströmten Gefäß. Biomed. Techn.21, 86–91 (1976)
Brantigan, J. W.: Accuracy of clinical blood gas measurements. J. Amer. med. Ass.229, 1923 (1974)
Brantigan, J. W., Dunn, K. L., Albo, D.: A clinical catheter for continuous blood gas measurement by mass spectrometry. personal communication (1976)
Brantigan, J. W., Gott, V. L., Martz, M. N.: A Teflon membrane for measurement of blood and intramyocardial gas tensions by mass spectroscopy. J. appl. Physiol.32, 276–282 (1972)
Brantigan, J. W., Gott, V. L., Vestal, M. L., Fergusson, G. J., Jonston, W. H.: A nonthrombogenic diffusion membrane for continuous in vivo measurement of blood gases by mass spectrometry. J. appl. Physiol.28, 375–377 (1970)
Brantigan, J. W., Perna, A. M., Gordner, T. J., Gott, V. L.: Intramyocardial gas tensions in the canine heart during anoxic cardiac arrest. Surgery, Gynec. Obstet.134, 67–72 (1972)
Brunnée, C., Voshage, H.: Massenspektrometrie. München: Thiemig 1964
Homer, L. D., Denysyk, B.: Estimation of cardiac output by analysis of respiratory gas exchange. J. appl. Physiol.39, 159–165 (1975)
Huber, W. K.: Quadrupol-Massenspektrometer und deren Anwendung. Tg.-Beitrag “Moderne Methoden der Massenspektrometrie”, Stuttgart-Esslingen, pp. 1–18 (1973)
Jenden, D. J., Silverman, R. W.: A multiple specific ion detector and analog data processor for a gas chromatograph/quadrupole mass spectrometer system. J. Chromatogr. Sci.11, 601–606 (1973)
Kety, S. S.: The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol. Rev.3, 1–41 (1951)
Löllgen, H., v. Nieding, G., Krekeler, H., Smidt, U.: Mass spectrometric determination of partial pressures of gases in liquids. Pneumonologie151, 292–294 (1975)
Muysers, K., Smidt, U.: Respirations-Massenspektrometrie. III. B. Auswertung von Massenspektren und monoisotopischen Analysen. Stuttgart: Schattauer 1969
v. Nieding, G., Schuy, K. D., Krekeler, H., Muysers, K.: Mass spectrometric determination of gas contents in microvolumes of liquids. A novel gas equilibration method. Pflügers Arch.335, R 31, 61 (1972)
Nishi, I.: A mass spectrometric system equipped with multicollectors and peak selectors for continuous gas analysis. Mass Spectrosc.22, 15–23 (1974)
Nishi, I., Sugai, S., Kimura, K.: Precision and Accuracy of mass spectrometer analysis in the direct gas inlet system (Fundamental consideration for respiratory gas analysis). Jap. J. appl. Physiol., Suppl.2, 163–166 (1974)
v. Oertzen, H.-D.: Der Verteilungskoeffizient von Argon zwischen Myocard und Blut sowie zwischen Niere und Blut. Diss., Göttingen 1972
Rau, G.: Messung der Koronardurchblutung mit der Argon-Fremdgasmethode. Arch. Kreisl.-Forsch.58, 322–398 (1969)
Roth, E. M.: Physical chemistry of Inert Gases. Part III/1 from “Space-Cabin Atmospheres”, pp. 1–9. Washington 1967
Turney, St. Z., McAslan, T. C., Cowley, R. A.: The continuous measurement of pulmonary gas exchange and mechanics. Ann. thorac. Surg.13, 229–242 (1972)
Wagner, P. D., Laravuso, R. B., Uhl, R. R., West, J. B.: Continuous distributions of ventilation-perfusion ratios in normal subjects breathing air and 100% O2. J. clin. Invest.54, 54–68 (1974)
Wagner, P. D., Naumann, P. F., Laravuso, R. B.: Simultaneous measurement of eight foreign gases in blood by gas chromatography. J. appl. Physiol.36, 600–605 (1974)
Wagner, P. D., Saltzman, H. A., West, J. B.: Measurement of continuous distributions of ventilation-perfusion ratios: theory. J. appl. Physiol.36, 588–599 (1974)
Wald, A., Massia, V. D. B.: Principles of gas analysis of interest to anesthesiologists. N. Y. St. J. Med.65, 1859–1870 (1965)
Wald, A., Hass, W. K., Ransoloff, J.: Tutorial: Experience with a mass spectrometer system for blood gas analysis in humans. J. Ass. Advanc. med. Instrum.5, 325–342 (1971)
Woldring, S.: Tutorial: Biomedical application of mass spectrometry for monitoring partial pressures. J. Ass. Advanc. med. Instrum.4, 43–56 (1970)
Author information
Authors and Affiliations
Additional information
Supported by the Bundesministerium für Forschung und Technologie
Rights and permissions
About this article
Cite this article
Beste, K.W., Duchanova, H., Hellige, G. et al. Quadrupole mass filtering for registration of blood gas partial pressures. Pflugers Arch. 365, 249–255 (1976). https://doi.org/10.1007/BF01067025
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01067025