Advertisement

Behavior Genetics

, Volume 2, Issue 1, pp 3–19 | Cite as

The investigation of linkage between a quantitative trait and a marker locus

  • J. K. Haseman
  • R. C. Elston
Article

Abstract

Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-allele locus that governs a quantitative trait. Random mating and linkage equilibrium are assumed. Also given are parametric and nonparametric methods for detecting linkage when the trait in question is governed by several two-allele loci, provided there is no epistasis.

Keywords

Quantitative Trait Random Mating Marker Locus Nonparametric Method Linkage Equilibrium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Cotterman, C. W. (1969). Factor-union phenotype systems. In Morton, N. E. (ed.),Computer Applications in Genetics, University of Hawaii Press, Honolulu, pp. 1–19.Google Scholar
  2. Graybill, F. A. (1961).An Introduction to Linear Statistical Models, McGraw-Hill, New York.Google Scholar
  3. Haseman, J. K. (1970). The genetic analysis of quantitative traits using twin and sib data. Unpublished Ph.D. thesis, University of North Carolina.Google Scholar
  4. Haseman, J. K., and Elston, R. C. (1970). The estimation of genetic variance from twin data.Behav. Genet. 1: 11–20.PubMedGoogle Scholar
  5. Kaplan, E. B., and Elston, R. C. (1972).A Subroutine Package for Maximum Likelihood Estimation (MAXLIK). Institute of Statistics Mimeo Series, University of North Carolina.Google Scholar
  6. Kempthorne, O. (1957).An Introduction to Genetic Statistics, John Wiley, New York.Google Scholar
  7. Kendall, M. G. (1955).Rank Correlation Methods, Charles Griffin, London.Google Scholar
  8. Li, C. C. (1955).Population Genetics, University of Chicago Press, Chicago.Google Scholar
  9. Penrose, L. S. (1938). Genetic linkage in graded human characters.Ann. Eugen. 6: 133–138.Google Scholar
  10. Siegel, S. (1956).Nonparametric Statistics for the Behavioral Sciences McGraw Hill, New York.Google Scholar

Copyright information

© Plenum Publishing Corporation 1972

Authors and Affiliations

  • J. K. Haseman
    • 1
  • R. C. Elston
    • 2
  1. 1.National Institute of Environmental Health SciencesResearch Triangle Park
  2. 2.Department of Biostatistics and the Genetics CurriculumUniversity of North CarolinaChapel Hill

Personalised recommendations