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Role of RNA and protein in memory storage: A review

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Abstract

The literature on the possible role of RNA and protein in long-term memory is reviewed in terms of the following five criteria: (1) The molecule should have a defined role in normal brain function. (2) There should be a quantitative and/or qualitative change in the molecule as a function of learning. (3) The molecule should lead to some type of relatively permanent change in the functioning of the brain. (4) Altered synthesis or utilization of the molecule should lead to predictable consequences for memory. (5) The localization of the response should be consistent in terms of the utilization of that portion of the brain in the particular task.

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Author notes

  1. Lynda L. Uphouse

    Present address: Department of Psychology, Yale University, New Haven, Connecticut

Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, California

    Lynda L. Uphouse

  2. Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado

    James W. MacInnes & Kurt Schlesinger

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Supported in part by U.S. Public Health Service grants MH-11167, MH-13026, and NS-09131. L. L. U. was supported in part by NICHD postdoctoral fellowship 1F02-HD52521-01.

Deceased.

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Uphouse, L.L., MacInnes, J.W. & Schlesinger, K. Role of RNA and protein in memory storage: A review. Behav Genet 4, 29–81 (1974). https://doi.org/10.1007/BF01066705

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