Mean residence time in peripheral tissue
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The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.
Key wordsmean residence time peripheral tissue mean residence time local mean transit time first-pass mean residence time area under the curve area under the moment curve peripheral tissue, tissue distribution compartmental model
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