Mean residence time in peripheral tissue

  • Patrick J. McNamara
  • Joseph C. Fleishaker
  • Thomas L. Hayden
Scientific Note


The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.

Key words

mean residence time peripheral tissue mean residence time local mean transit time first-pass mean residence time area under the curve area under the moment curve peripheral tissue, tissue distribution compartmental model 


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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Patrick J. McNamara
    • 1
  • Joseph C. Fleishaker
    • 1
  • Thomas L. Hayden
    • 2
  1. 1.Division of Pharmaceutics and Pharmaceutical Analysis, College of PharmacyUniversity of KentuckyLexington
  2. 2.Mathematics DepartmentUniversity of KentuckyLexington

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