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Hypothalamic-pituitary-adrenal axis function in children with attention-deficit hyperactivity disorder

  • Motohisa Kaneko
  • Yoshihiko Hoshino
  • Shinichi Hashimoto
  • Takaaki Okano
  • Hisashi Kumashiro
Article

Abstract

Examined hypothalamic-pituitary-adrenal axis (HPA axis) function in 30 children with attention-deficit hyperactivity disorder (ADHD) by measuring the diurnal variation and response to the dexamethasone suppression test (DST) of saliva cortisol. Normal diurnal saliva cortisol rhythm was found in only 43.3% of the ADHD children. DST showed suppression in 46.7% of the ADHD children. An abnormal diurnal rhythm and nonsuppression to the DST were more frequent in the severely hyperactive group than in the mildly hyperactive group of children with ADHD. These results suggest abnormalities in HPA axis function in some children with ADHD, especially those exhibiting severe hyperactivity.

Keywords

Cortisol Dexamethasone Diurnal Variation Suppression Test Diurnal Rhythm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Motohisa Kaneko
    • 1
  • Yoshihiko Hoshino
    • 1
  • Shinichi Hashimoto
    • 1
  • Takaaki Okano
    • 1
  • Hisashi Kumashiro
    • 1
  1. 1.Department of NeuropsychiatryFukushima Medical CollegeFukushima-shi FukushimaJapan

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