Abstract
Micromolar concentrations of cycloheximide (CH) can be used to test for genetic differences in the ability to taste bitter substances. Three related strains of rats — Fawn-hooded, Long Evans, and Wistar — differ significantly in their ability to taste this substance, the former being unusually deficient in this respect. Wistar and Long Evans rats are able to perceive millimolar concentrations of phenylthiocarbamide (PTC) and 0.2 μM CH. FH animals are unable to detect millimolar PTC and first recognize CH when it is present in 1.5 μM concentration.
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Tobach, E., Bellin, J.S. & Das, D.K. Differences in bitter taste perception in three strains of rats. Behav Genet 4, 405–410 (1974). https://doi.org/10.1007/BF01066160
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DOI: https://doi.org/10.1007/BF01066160