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Gas chromatographic determination and pharmacokinetics of 4-hydroxybutyrate in dog and mouse

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Abstract

A rapid and reproducible method was developed to extract 4-hydroxybutyrate from plasma as 4-butyrolactone for subsequent gas chromatographic (GLC) assay. The drug, an intravenous anesthetic and oral hypnotic in man, was infused into four dogs and the plasma concentration was determined by 14 C-isotope dilution and GLC. Pharmacokinetic parameters for distribution and elimination were calculated. A capacity-limited process appears to be involved in the elimination of 4-hydroxybutyrate in the dog. Macroautoradiography revealed the distribution pattern in normal and pregnant adult mice.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, St. Radboud Hospital, Cathoiic University of Nijmegen, The Netherlands

    Willem van der Pol & Eppo van der Kleijn

  2. Department of Anesthesiology, Medical School, St. Radboud Hospital, Catholic University of Nijmegen, The Netherlands

    Martin Lauw

Authors
  1. Willem van der Pol
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  2. Eppo van der Kleijn
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  3. Martin Lauw
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van der Pol, W., van der Kleijn, E. & Lauw, M. Gas chromatographic determination and pharmacokinetics of 4-hydroxybutyrate in dog and mouse. Journal of Pharmacokinetics and Biopharmaceutics 3, 99–113 (1975). https://doi.org/10.1007/BF01066018

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  • DOI: https://doi.org/10.1007/BF01066018

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