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Applications of a simplified triple-test cross

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Abstract

A simplified triple-test cross (TTC) involving only inbred lines is outlined and compared with the diallel cross. The TTC is more economical than the diallel cross, employs a more rigorous test of epistasis, and leads to a better estimate of the level of dominance. Its main limitation is that, unlike the diallel cross, only a single phenotype may generally be investigated in any one study. Six applications to the behavior of Drosophila melanogaster, mice, and rats indicate that the two designs lead to very similar conclusions. An augmented half diallel cross is suggested as a powerful compromise design.

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Authors and Affiliations

  1. Department of Psychology, University of Birmingham, Birmingham, England

    D. W. Fulker

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  1. D. W. Fulker
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Additional information

This work was supported by a (British) Medical Research Council grant for research into psychogenetics.

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Fulker, D.W. Applications of a simplified triple-test cross. Behav Genet 2, 185–198 (1972). https://doi.org/10.1007/BF01065689

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