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Role of intramuscular administration of water-in-oil emulsions as a method for increasing the delivery of anticancer to regional lymphatics

Journal of Pharmacokinetics and Biopharmaceutics volume 5, pages 225–239 (1977)Cite this article

Abstract

Further work was undertaken to clarify the mechanism of enhanced delivery of anticancer agents into rat lymph nodes by water-in-oil (W/O) emulsions. Radiolabeled [131I] iodohippuric acid (IH, watersoluble model compound) and [14C]tripalmitin (TP, tracer of oil) were administered intramuscularly, and radioactive concentrations in blood, lymph nodes, and muscles were determined. Also, a new type of emulsion, gelatin-containing W/O (W/O-G) emulsion, was manufactured to be used as a delivery system for the anticancer agents. It was found that the rate of transfer of TP into lymph nodes was enhanced in the following order: oil, oil-in-water (O/W) emulsion, W/O emulsion, and W/O-G emulsion. The transfer of IH into lymph nodes was enhanced more effectively by W/O-G emulsion. The results of this study suggest the existence of a special transport mechanism through which drug and oil are delivered together.

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References

  1. Y. Nakamoto, M. Fujiwara, T. Noguchi, T. Kimura, S. Muranishi, and H. Sezaki. Studies on pharmaceutical modification of anticancer agents. I. Enhancement of lymphatic transport of mitomycin C by parenteral emulsions.Chem. Pharm. Bull. 23:2232–2238 (1975).

    CAS  PubMed  Article  Google Scholar 

  2. Y. Nakamoto, M. Hashida, S. Muranishi, and H. Sezaki. Studies on pharmaceutical modification of anticancer agents. II. Enhanced delivery of bleomycin into lymph by emulsions and drying emulsions.Chem. Pharm. Bull. 23:3125–3131 (1975).

    CAS  PubMed  Article  Google Scholar 

  3. K. Kakemi, H. Sezaki, K. Okumura, and S. Ashida, Absorption and excretion of drugs. XXXIX. The absorption of isonicotinic acid derivatives from the skeletal muscle of the rats.Chem. Pharm. Bull. 17:1332–1338 (1969).

    CAS  PubMed  Article  Google Scholar 

  4. M. Tubis, E. Posnick, and R. A. Nordyke. Preparation and use of131I labeled sodium iodohippurate in kidney function tests.Proc. Soc. Exp. Biol. Med. 103:497–498 (1960).

    CAS  PubMed  Article  Google Scholar 

  5. J. N. Bollinger. Metabolic fate of mineral oil adjuvants using14 C-labeled tracers. I. Mineral oil.J. Pharm. Sci. 59:1084–1088 (1970).

    CAS  PubMed  Article  Google Scholar 

  6. J. N. Bollinger. Metabolic fate of mineral oil adjuvants using14 C-labeled tracers. II. Mannide monooleate.J. Pharm. Sci. 59:1088–1092 (1970).

    CAS  PubMed  Article  Google Scholar 

  7. T. Nishimura, H. Kobayashi, K. Okumura, S. Muranishi, and H. Sezaki. Intramuscular absorption of drugs from the oily solutions in the rat.Chem. Pharm. Bull. 22:1275–1284 (1974).

    Article  Google Scholar 

  8. D. T. Mahin and R. T. Loftberg. A simplified method of sample preparation for determination of tritium, carbon-14, or sulfur-35 in blood or tissue by liquid scintillation counting.Anal. Biochem. 16:500–509 (1966).

    CAS  Article  Google Scholar 

  9. N. L. Tilney. Patterns of lymphatic drainage in the adult laboratory rat.J. Anat. 109:369–383 (1971).

    CAS  PubMed Central  PubMed  Google Scholar 

  10. B. E. Ballard. Biopharmaceutical considerations in subcutaneous and intramuscular drug administration.J. Pharm. Sci. 57:357–378 (1968).

    CAS  PubMed  Article  Google Scholar 

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Affiliations

  1. Facuity of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

    Mitsuru Hashida, Mitsuo Egawa, Shozo Muranishi & Hitoshi Sezaki

Authors
  1. Mitsuru Hashida
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  2. Mitsuo Egawa
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  3. Shozo Muranishi
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  4. Hitoshi Sezaki
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Hashida, M., Egawa, M., Muranishi, S. et al. Role of intramuscular administration of water-in-oil emulsions as a method for increasing the delivery of anticancer to regional lymphatics. Journal of Pharmacokinetics and Biopharmaceutics 5, 225–239 (1977). https://doi.org/10.1007/BF01065397

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  • DOI: https://doi.org/10.1007/BF01065397

Key words

  • drug delivery system
  • anticancer agent
  • water-in-oil emulsion, gelatincontaining water-in-oil emulsion
  • intramuscular injection
  • lymph nodes
  • enhanced delivery into the lymphatic system
  • sustained release