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Pharmacokinetics of ethanol after oral administration in the fasting state

  • Paul K. Wilkinson
  • Allen J. Sedman
  • Ermelinda Sakmar
  • Donald R. Kay
  • John G. Wagner
Article

Abstract

A nonlinear relationship between the total area under the blood ethanol concentration-time curve and the orally administered dose (mg/kg) of ethanol was observed in fasting subjects. A preliminary model, based on physiological considerations, was elaborated and shown, for the first time, to describe the entire time course of blood alcohol concentrations after four different doses of alcohol. The model could be refined by further experimentation.

Key words

nonlinear pharmacokinetics Michaelis-Menten kinetics gastric emptying rate blood alcohol concentrations 

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Copyright information

© Plenum Publishing Corp. 1977

Authors and Affiliations

  • Paul K. Wilkinson
    • 1
    • 2
  • Allen J. Sedman
    • 1
  • Ermelinda Sakmar
    • 1
  • Donald R. Kay
    • 1
  • John G. Wagner
    • 1
  1. 1.College of Pharmacy and Upjohn Center for Clinical PharmacologyThe University of MichiganAnn Arbor
  2. 2.School of PharmacyAuburn UniversityAuburn

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