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Reduction by thiopental of the slow-channel-mediated action potential of canine papillary muscle

  • Excitable Tissues And Central Nervous Physiology
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Summary

The negative inotropic effect of thiopental was examined on the canine papillary muscle. The slow-channel-mediated action potential was induced by 5mM of caffeine in high-K (27 mM) Tyrode solution. The drug reduced the slow action potential and the twitch tension, suggesting a reduction in the slow inward current.

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Author notes

  1. Yoshimi Ikemoto

    Present address: Department of Anesthesiology, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan

Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan

    Yoshimi Ikemoto

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  1. Yoshimi Ikemoto
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Ikemoto, Y. Reduction by thiopental of the slow-channel-mediated action potential of canine papillary muscle. Pflugers Arch. 372, 285–286 (1977). https://doi.org/10.1007/BF01063865

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  • DOI: https://doi.org/10.1007/BF01063865

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