Skip to main content

Unitary responses of the hypothalamic nuclei to stimulation of the frontobasal neocortex

Abstract

Unitary responses in the hypothalamic nuclei to stimulation of the frontobasal zones of the cortex (proreal, orbito-insular, and basal temporal regions) were studied. Cortico-thalamic connections were found to possess definite topical organization: the orbito-frontal zones of the cortex have a more marked effect on unit activity of the hypothalamic nuclei than the basal temporal cortex. Antidromic activation, during stimulation of a particular region of the cortex, of neurons excited orthodromically by stimulation of another cortical structure, enables a number of neuronal circuits functioning within the forebrain to be distinguished. The first circuit includes the orbital gyrus, preoptic zone, and proreal gyrus. The second circuit has the same cortical components as the first, but its relay in the hypothalamus takes place in the region of the mamillary bodies. The third circuit is represented by the basal temporal cortex, lateral hypothalamus, and prefrontal cortex.

This is a preview of subscription content, access via your institution.

Literature cited

  1. O. G. Baklavadzhyan, A. G. Arkelyan, and L. A. Balasonyan, "Analysis of evoked discharges in hypothalamic neurons to somatosensory, acoustic, and photic stimulation," Neirofiziologiya,3, 592 (1971).

    Google Scholar 

  2. V. G. Zilov, "Interaction between cortical and reticular influences on neurons of the lateral hypothalamus," Fiziol. Zh. SSSR,55, 1436 (1969).

    Google Scholar 

  3. N. I. Dubrovina and R. Yu. Il'yuchenok, "Comparative effects of amygdala and central gray matter of the midbrain on lateral hypothalamic unit activity," Neirofiziologiya,9, 25 (1977).

    Google Scholar 

  4. V. N. Kazakov, "Functional organization and connections of the orbitofrontal cortex," Author's Abstract of Doctoral Dissertation, Odessa (1971), 24 pp.

  5. V. N. Kazakov, P. Ya. Kravtsov, and V. N. Rassokhin, "Electrophysiological studies of cortico-hypothalamic relations in the cat," Neirofiziologiya,8, 358 (1976).

    Google Scholar 

  6. G. I. Kiknadze, "Structural organization and connections of the proreal gyrus of the cerebral cortex," Author's abstract of Candidate's Dissertation, Tbilisi, (1969), 17 pp.

  7. P. Ya. Kravtsov, "The role of corticofugal influence in unit activity of hypothalamic structures," Authors' Abstract of Candidate's Dissertation, Donetsk (1976), 21 pp.

  8. A. I. L'vovich, "Cortico-mammillary pathways of the brain," Arkh. Anat. Gistol. Émbriol.,61, 64 (1971).

    Google Scholar 

  9. F. N. Serkov, E. Sh. Yanovskii, and A. I. Tal'nov, "Functional properties distinguishing individual auditory cortical neurons," Neirofiziologiya,5, 236 (1973).

    Google Scholar 

  10. K. V. Sudakov, "A study of ascending activating influences on the cortex during starvation and by local polarization of the hypothalamus," Fiziol. Zh. SSSR,49, 901 (1963).

    Google Scholar 

  11. W. R. Adey and M. Meyer, "Hippocampal and hypothalamic connections of the temporal lobe in the monkey," Brain,75, 358 (1952).

    Google Scholar 

  12. P. Gloor, J. T. Murphy, and J. J. Dreifuss, "Anatomical and physiological characteristics of the two amygdaloid projection systems to the ventromedial hypothalamus," in: Limbic Mechanisms and Autonomic Function, Thomas, Springfield, Ill. (1972).

    Google Scholar 

  13. M. Ito, "Activation and inhibition of the lateral hypothalamic neurons elicited by medial forebrain bundle stimulation," J. Physiol. (London),254, 109 (1976).

    Google Scholar 

  14. H. Hasper and C. Ajmone-Marsan, A Stereotaxic Atlas of the Diencephalon of the Cat, National Research Council of Canada, Ottawa (1954).

    Google Scholar 

  15. K. Koizumi, T. Ishikawa, and M. C. Brooks, "Control of activity of neurons in the supraoptic nucleus," J. Neurophysiol.,5, 875 (1964).

    Google Scholar 

  16. J. Marsala, "Efferente frontostriatische, frontohypothalamische und frontothalamische Bahren des Gehirns der Katze," Biol. Prace,11, No. 7, 95 (1965).

    Google Scholar 

  17. J. T. Murphy, J. J. Dreifuss, and P. Gloor, "Topographical differences in the responses of single hypothalamic neurons to limbic stimulation," Am. J. Physiol.,214, 1443 (1968).

    Google Scholar 

  18. O. Millhouse, "A Golgi study of the descending medial forebrain bundle," Brain Res.,15, 341 (1969).

    Google Scholar 

  19. J. T. Murphy and L. P. Renaud, "Synaptic events produced by activation of the amygdalofugal pathways to the hypothalamic ventromedial nucleus," in: Limbic System Mechanisms and Autonomic Function, C. C. Thomas, Springfield, Illinois (1972), pp. 78–82.

    Google Scholar 

  20. W. J. H. Nauta, "Some efferent connections of the prefrontal cortex in the monkey," in: The Frontal Cortex and Behavior, McGraw-Hill, New York (1964), pp. 397–409.

    Google Scholar 

  21. W. J. H. Nauta, "Neural associations of the frontal cortex," Acta Neurobiol. Exp.,2, 125 (1972).

    Google Scholar 

  22. C. G. Phillips, "Actions of antidromic pyramidal volleys on single Betz cells in the cat," Quart. J. Exp. Physiol.,44, 1 (1959).

    Google Scholar 

  23. M. Rasminsky, A. J. Mauro, and D. Albe-Fessard, "Projections of medial thalamic nuclei to putamen and cerebral frontal cortex in the cat," Brain Res.,61, 69 (1973).

    Google Scholar 

  24. E. Sachs, S. Brendier, and L. Fulton, "The orbital gyri," Brain,72, 227 (1949).

    Google Scholar 

  25. M. E. Scheibel and A. B. Scheibel, "The organization of the nucleus reticularis thalami: a Golgi study," Brain Res.,1, 43 (1966).

    Google Scholar 

  26. A. Ward and W. S. McCulloch, "The projection of the frontal lobe on the hypothalamus," J. Neurophysiol.,10, 309 (1947).

    Google Scholar 

  27. F. Valverde, "Studies on the forebrain of the mouse: Golgi observation," J. Anat.,97, 157 (1963).

    Google Scholar 

  28. D. G. Whitlock and W. J. Nauta, "Subcortical projections from temporal neocortex inMacaca mulatta," J. Comp. Neurol.,106, 183 (1956).

    Google Scholar 

Download references

Authors

Additional information

M. Gor'kii Donetsk Medical Institute. Translated from Neirofiziologiya, Vol. 10, No. 1, pp. 44–53, January–February, 1978.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kazakov, V.N., Kravtsov, P.Y. Unitary responses of the hypothalamic nuclei to stimulation of the frontobasal neocortex. Neurophysiology 10, 33–40 (1978). https://doi.org/10.1007/BF01063345

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01063345

Keywords

  • Prefrontal Cortex
  • Temporal Region
  • Marked Effect
  • Unit Activity
  • Temporal Cortex