Abstract
A flow-limited multicompartment model simulates the distribution and disposition of phenol red in the dogfish after intravenous administration. Glucuronide conjugate, as well as parent compound, was found in urine and bile, but not in plasma, kidney, or liver tissue. An apparent 4-hr lag in phenol red appearance in the gall bladder was simulated using two stirred tanks connected in series to represent the bile ducts. The model should facilitate use of the dogfish in pharmacokinetic studies of drugs, environmental contaminants, and other xenobiotics.
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Bungay, P.M., Dedrick, R.L. & Guarino, A.M. Pharmacokinetic modeling of the dogfish shark (Squalus acanthias): Distribution and urinary and biliary excretion of phenol red and its glucuronide. Journal of Pharmacokinetics and Biopharmaceutics 4, 377–388 (1976). https://doi.org/10.1007/BF01062827
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DOI: https://doi.org/10.1007/BF01062827