Abstract
Nonlinear least-squares regression can be performed on a microcomputer with BASIC language capability and 8K or more bytes of random access memory. At least five nonlinear regression programs written in BASIC exist, two of which have been implemented on microcomputers. These programs and some of their characteristics are described. Advantages and disadvantages of performing nonlinear regression on microcomputers are contrasted with use of nonlinear regression programs requiring large computers.
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References
R. D. Brown and J. E. Manno. ESTRIP, a BASIC computer program for obtaining initial polyexponential parameter estimates.J. Pharm. Sci. 67:1687–1691 (1978).
A. J. Sedman and J. G. Wagner, CSTRIP, a FORTRAN IV computer program for obtaining initial polyexponential parameter estimates.J. Pharm. Sci. 65:1006–1010 (1976).
P. V. Pedersen. Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT.J. Pharmacokin. Biopharm. 5:513–531 (1977).
C. M. Metzler.A Users Manual for NONLIN, Upjohn Co., Technical Report 7292/69/7292/005, Kalamazoo, Mich., 1969.
W. J. Dixon.BMD Biomedical Computer Programs, University of California Press, Berkeley, 1974.
W. J. Dixon and M. B. Brown.BMDP-77 Biomedical Computer Programs P-Series, University of California Press, Berkeley, 1977.
M. Berman and M. F. Weiss.Users Manual for SAAM, National Institutes of Healh, Bethesda, Md., 1968.
J. D. Powers, T. E. Powers, J. D. Baggot, J. Kowalski, and K. Kerr. Automated processing of data from pharmacokinetic investigations.Comput. Biomed. Res. 9:543–548 (1976).
K. M. Brown.Computer Oriented Methods for Fitting Tabular Data in the Nonlinear Least Squares Sense, Fall Joint Computer Conference, 1972, p. 1309.
M. Pfeffer. COMPT, a time-sharing program for nonlinear regression analysis of compartmental models of drug distribution.J. Pharmacokin. Biopharm. 1:137–163 (1973).
C. Patlak and K. Pettigrew. Theoretical and Mathematics Branch, National Institute of Mental Health, NIH., Bethesda, Md., personal communication, 1976.
D. L. Horowitz and L. D. Homer.Analysis of Biomedical Data by Time-sharing Computers. I. Non-linear Regression Analysis, Project No. MR005:20-0287, Report No. 25, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Md. 20014, Feb. 26, 1970.
PLOT 50 Statistics. InNonlinear Regressions, Vol. 4, Tektronix, Inc., Information Display Group, Beaverton, Ore. 1977.
Non-Linear Regression (System 45), Hewlett Packard, Inc., Santa Clara, Calif. 95014, 1978.
R. Desjardins and C. Pamplin. Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, D.C., personal communication, 1977.
C. C. Peck and L. Z. Benet. General method for determining macrodissociation constants of polyproptic, amophoteric compounds from solubility measurements.J. Pharm. Sci. 67:12–16 (1978).
H. I. Friedman, J. G. Chandler, C. C. Peck, T. J. Nemeth, and S. K. Odum. Alterations in intestinal structure, fat absorption and body weight after intestinal bypass for morbid obesity.Surg. Gynecol. Obstet. 146:757–767 (1978).
C. C. Peck, D. G. Odom, H. I. Friedman, P. W. Albro, J. R. Hass, H. T. Brady, and D. A. Jess. Di-2-ethylhexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) accumulation in whole blood and red cell concentrates.Transfusion 19:137–146 (1979).
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The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense (Para. 4-3, AR 360-5).
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Peck, C.C., Barrett, B.B. Nonlinear least-squares regression programs for microcomputers. Journal of Pharmacokinetics and Biopharmaceutics 7, 537–541 (1979). https://doi.org/10.1007/BF01062394
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DOI: https://doi.org/10.1007/BF01062394