Bioavailability studies on para-aminosalicylic acid and its various salts in man. I. Absorption from solution and suspension
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The relative bioavailability of PAS and the sodium, potassium, and calcium salts of PAS has been studied. Absorption of PAS and its three salts is essentially complete. Dissolution of PAS appears to be a rate-limiting factor in its absorption. The type of salt administered affects the rate of absorption. Although absorption of all four compounds was complete, the areas under the plasma concentration-time curve, or bioavailable drug, are dependent on the rate of absorption. The data presented show evidence of rate-limited metabolism, especially in the first pass.
Key wordsbioavailability PAS absorption first-pass effect
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