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Bioavailability studies on para-aminosalicylic acid and its various salts in man. I. Absorption from solution and suspension

  • Suk Han Wan
  • Pertti Pentikainen
  • Daniel L. Azarnoff
Article

Abstract

The relative bioavailability of PAS and the sodium, potassium, and calcium salts of PAS has been studied. Absorption of PAS and its three salts is essentially complete. Dissolution of PAS appears to be a rate-limiting factor in its absorption. The type of salt administered affects the rate of absorption. Although absorption of all four compounds was complete, the areas under the plasma concentration-time curve, or bioavailable drug, are dependent on the rate of absorption. The data presented show evidence of rate-limited metabolism, especially in the first pass.

Key words

bioavailability PAS absorption first-pass effect 

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Copyright information

© Plenum Publishing Corporation 1974

Authors and Affiliations

  • Suk Han Wan
    • 1
  • Pertti Pentikainen
    • 1
  • Daniel L. Azarnoff
    • 1
  1. 1.Clinical Pharmacology-Toxicology Center, Departments of Medicine and PharmacologyUniversity of Kansas Medical CenterKansas City

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