Abstract
A deconvolution method is presented for use in pharmacokinetic applications involving continuous models and small samples of discrete observations. The method is based on the continuous-time counterpart of discrete-time least squares system identification, well established in control engineering. The same technique, requiring only the solution of a linear regression problem, is used both in system identification and input identification steps. The deconvolution requires no a prioriinformation, since the proposed procedure performs system identification (including optimal selection of model order), selects the form of the input function and calculates its parametric representation and its values at specified time points.
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On leave from Eötvös Lorand University, Budapest, Hungary.
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Vajda, S., Godfrey, K.R. & Valko, P. Numerical deconvolution using system identification methods. Journal of Pharmacokinetics and Biopharmaceutics 16, 85–107 (1988). https://doi.org/10.1007/BF01061863
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DOI: https://doi.org/10.1007/BF01061863