Abstract
The kinetics of propylthiouracil in man was evaluated in four subjects after intravenous infusion at different infusion rates. Significant correlation among the rate of infusion, steadystate plasma levels, and AUC sustained the assumption of a doseindependent kinetics. The total body clearance and the elimination halflife evaluated after cessation of the infusion were in close agreement with values obtained in a previous study after intravenous bolus injection. The total volume of distribution was larger after infusion than found in the singleinjection studies. Data obtained from the infusions made it possible to evaluate the a phase indirectly.
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This work was supported by Grant 512-4121 from the Danish Medical Research Council, Copenhagen.
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Kampmann, J.P. Pharmacokinetics of propylthiouracil in man after intravenous infusion. Journal of Pharmacokinetics and Biopharmaceutics 5, 435–443 (1977). https://doi.org/10.1007/BF01061727
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DOI: https://doi.org/10.1007/BF01061727