Summary
Twelve healthy volunteers were given a single oral dose of dipyrone 1 g, once while fasting and once after a standard breakfast. Plasma levels of the active dipyrone metabolite — Methylaminoantipyrine (MAA) were measured and the calculated pharmacokinetic parameters were compared.
Taking dipyrone with food resulted in a small delay in the mean time to peak from 1.5 h to 1.9 h (p<0.01). However, there was no significant difference in AUC, Cmax or Kelim between fasting and nonfasting conditions. The rate of absorption, expressed as the mean Kabs, was somewhat slower in the nonfasting state, but not significantly so.
It is suggested that dipyrone may be taken regardless of the times of eating.
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Flusser, D., Zylber-Katz, E., Granit, L. et al. Influence of food on the pharmacokinetics of dipyrone. Eur J Clin Pharmacol 34, 105–107 (1988). https://doi.org/10.1007/BF01061429
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DOI: https://doi.org/10.1007/BF01061429