Summary
The present study was designed to determine the single- and multiple-dose pharmacokinetic profiles of the H2 receptor antagonist etintidine in healthy volunteers.
Etintidine was rapidly absorbed and eliminated after the oral administration of 300 mg base equivalent of etintidine HCl in a capsule formulation to 11 healthy subjects. Comparison of the pharmacokinetics after a single dose and during steady state showed no significant differences (p>0.05) in the mean values of Cmax, tmax, oral clearance, elimination rate constant, and renal clearance, indicating no significant accumulation of etintidine and no apparent time-dependent changes in the pharmacokinetics of etintidine during multiple dose administration.
References
Brater DC, Meyers WM, Dandekar KA, Pittman KA, Peterson W (1982) Clinical pharmacology of etintidine in patients with duodenal ulcer. Eur J Clin Pharmacol 23: 495–500
Gibaldi M, Perrier D (1982) Pharmacokinetics, 2nd edn. Marcel Dekker, New York
Wagner JG (1975) Fundamentals of clinical pharmacokinetics. Drug Intelligence Publications, Hamilton, IL, pp 301–303
Riegelman S, Collier P (1980) The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time. J Pharmacokinet Biopharm 8: 509–534
Jusko WJ (1980) Guidelines for collection and pharmacokinetic analysis of drug disposition data. In: Evans WE, Schentag JJ, Jusko WJ (eds) Applied pharmacokinetics: Principles of therapeutic drug monitoring, chapter 20. Applied Therapeutics, San Francisco, CA
Ray AA, Sall JP (1982) SAS user's guide: Statistics. SAS Institute, Raleigh, NC
Chin T, MacLeod S, Spino M, Soldin S, Mahon W (1983) Cimetidine (CMT) kinetics after subchronic dosing. Clin Pharmacol Ther 33: 250
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Huang, S.M., Marriott, T.B., Weintraub, H.S. et al. Single-dose and multiple-dose pharmacokinetics of etintidine in healthy volunteers. Eur J Clin Pharmacol 34, 101–104 (1988). https://doi.org/10.1007/BF01061428
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01061428