Summary
426 consecutive patients admitted to a Danish University Department of Cardiology have been studied. Drug intake prior to admission by each patient was ascertained from medical records and personal interviews. Adverse drug reactions (ADR) were the primary cause of admission in 49 patients (11.5%), and 16 patients (3.8%) were admitted due to drug non-compliance (DNC).
Thiazide diuretics, beta-adrenoceptor blocking agents and calcium antagonists accounted for almost 60% of all the ADR-related admissions. Patients admitted for ADR took significantly more drugs than patients admitted for other reasons. DNC was not correlated with the number of prescribed drugs.
It is concluded that drug-related hospital admissions are an important medical and economic problem. Most of the ADRs were well-known and predictable actions of the drugs, and could have been avoided by more careful clinical and laboratory monitoring of the patients. Most of the DNC, too, could have been avoided by giving better information to the patients.
References
Andersen T, Nielsen JK, Christiansen LV, Falkenberg F, Østerlind AW, Olsen L, Christau S, Kampmann JP, Mølholm Hansen I (1978) Lægemiddelbivirkninger på kirurgisk afdeling. Ugeskr Læg 140: 799–802
Beerman B, Bjørck G, Groschinsky-Grind M (1978) Läkemedelsbivirkninger och intoxikationer som orsak till intagning på invärtesmedicinsk klinik. Läkartidningen 75: 958–960
Bergmann U, Wiholm B-E (1981) Drug-related problems causing admission to a medical clinic. Eur J Clin Pharmacol 20: 193–200
Hurwitz N, Wade OL (1969) Intensive hospital monitoring of adverse reactions to drugs. Br Med J 1: 531–536
Miller RR (1974) Hospital admissions due to adverse drug reactions. Arch Int Med 134: 219–223
Seidl LG, Thornton GF, Smith JW, Eluff LE (1966) Studies on the epidemiology of adverse drug reactions: III. Reactions in patients on a general medical service. Bull Johns Hopk Hosp 119: 299–315
WHO Technical Report Series No 498 (1972) International drug monitoring: The role of national centres. WHO, Geneva
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Davidsen, F., Haghfelt, T., Gram, L.F. et al. Adverse drug reactions and drug non-compliance as primary causes of admission to a cardiology department. Eur J Clin Pharmacol 34, 83–86 (1988). https://doi.org/10.1007/BF01061423
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DOI: https://doi.org/10.1007/BF01061423