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Influence of once-monthly rifampicin and daily clofazimine on the pharmacokinetics of dapsone in leprosy patients in Nigeria

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Summary

In leprosy patients in Nigeria the influence of daily clofazimine and of once-monthly rifampicin on the pharmacokinetics of dapsone has been investigated.

Three days after rifampicin the elimination half-life of dapsone was reduced from 40.4 to 25.3 h (n=23). Correspondingly, the plasma dapsone 24 h after the last dose had fallen significantly from 2.63 to 2.02 mg/l. Clofazimine did not cause change in the pharmacokinetics of dapsone.

It was concluded that, although rifamipicin had a considerable influence on the pharmacokinetics of dapsone, there is no reason to adjust the dose of dapsone during multidrug therapy of leprosy.

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Authors and Affiliations

  1. Department of Biopharmaceutics, University of Amsterdam, Amsterdam, The Netherlands

    F. A. J. M. Pieters & J. Zuidema

  2. Mangu Leprosy and Rehabilitation Centre (COCIN), Mangu, Plateau State, Nigeria

    F. Woonink

Authors
  1. F. A. J. M. Pieters
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  2. F. Woonink
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  3. J. Zuidema
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Pieters, F.A.J.M., Woonink, F. & Zuidema, J. Influence of once-monthly rifampicin and daily clofazimine on the pharmacokinetics of dapsone in leprosy patients in Nigeria. Eur J Clin Pharmacol 34, 73–76 (1988). https://doi.org/10.1007/BF01061421

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  • DOI: https://doi.org/10.1007/BF01061421

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