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Polypropylene surgical thread with complex biological activity

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Fibre Chemistry Aims and scope

Abstract

A method is proposed for giving polypropylene (PP) thread ion-exchange properties by chemically initiated grafting of polystyrene (PS) and subsequent sulfonation. Graft copolymerization is conducted in two stages: swelling of the thread in a solution of initiator in the monomer and heat treatment in indifferent aqueous medium. Sulfonation is best conducted with chlorosulfonic acid. Gentamicin, kanamycin, monomycin, tetracycline, trypsin, pepsin, and novocain were sorbed separately and together on the PP thread obtained. When antibiotics and enzymes were combined, the activity of the immobilized enzymes was synergistically potentiated. Medical and biological studies and preclinical and clinical trials demonstrated the high efficacy of the antimicrobial, proteolytic, and anesthetic action of the modified PP surgical thread.

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Authors
  1. V. A. Zhukovskii
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Additional information

St. Petersburg State University of Technology and Design. Translated from Khimicheskie Volokna, No. 6, pp. 12–16. Nobember–December. 1996.

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Zhukovskii, V.A. Polypropylene surgical thread with complex biological activity. Fibre Chem 28, 369–373 (1996). https://doi.org/10.1007/BF01060997

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  • DOI: https://doi.org/10.1007/BF01060997

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