Abstract
The intestinal transport of D-xylose was studied during subchronic poisoning of male Wistar rats with the oral administration of potassium nitrate and sodium nitrite. The metabolic parameters of small intestine mucosa were determined one hour after xylose administration,i.e., Na+/K+ -ATPase, alkaline phosphatase, oxygen consumption, and lactic acid level. Nitrite reduced the absorption of xylose and decreased the activity of Na+/K+ -ATPase and alkaline phosphatase. No effect of sodium nitrite was demonstrated on the aerobic metabolism of intestinal mucosa with an increased lactic acid level. Potassium nitrate did not effect the processes of intestinal absorption of xylose nor the metabolic parameters of small intestine mucosa.
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References
Bilczuk L (1976) The effect of sodium nitrite on the organism of rat. Roczn PZH 27:269–276
—,— (1980) Attempt of evaluation of vitamin A protective effect on rats exposed to prolonged action of sodium nitrite. Bromat Chem Toksykol 13:49–54
Bloomfield RA, Welsch CW, Garner GB, Muhrer ME (1962) Thyroid compensation under the influence of dietary nitrate. Proc Soc Exp Biol Med 111:288–290
Cazottes C, Fritsch P, Gas N, de Saint Blanquat G (1981) Nitrates and nitrites: Nutritional impacts in the rat. Ann Nutr Metab 25:182–193
Darad R, de Kumar A, Aliyar AS (1983) Toxicity of nitrite and dimethylamine in rats. Toxicol Letters 17:125–130
Fritch P, Canal MT, de Saint Blanquat G (1983) Experience en pair-feeding chez des rats traites au nitrate ou au nitrite de sodium. Ann Nutr Metab 27:38–47
Grudziński I, Szymański A (1989) Assessment of D/+/-xylose absorption in acute and subacute poisoning with potassium nitrate and sodium nitrite. Lek Wojsk 65:433–438
Grudziński I (1990) Nitrosoamines, nitrosoamides-carcinogens in the food. Lek Wojsk 66:225–228
Klassen WH, Lanzkowski P (1964) Determination of D/+/-xylose in blood Clin Chim Acta 9:183–185
Kubberod G, Cassens RG, Greaser ML (1974) Reaction of nitrite with sulphydryl groups of myosin. J Fd Sci 39:1228–1230
Lebeda M, Prikrylova J (1985) Observation on methemoglobinaemia in dairy cows during four years. Acta Vet Brno 54:157–168
Leutsky KM (1972) Biological investigation of vitamin A. J Biochim Ukr 44:771–776
Lhuissier M, Vernevaut MF (1977) Effects du nitrite de sodium sur les concentrations en diveres vitamines de tissus de rat. J Internat Vitaminol 48:79–83
Lowry OH, Rosenbrough NJ, Farr AL, Randell RJ (1952) Protein measurements with the Folin phenol reagent. J Biol Chem 193:265–275
Lowy R, Manchon Ph (1976) Effects toxiques divers des nitrates et des nitrites. Ann Nutr Alim 30:839–845
Mallett AK, Rowland IR, Cottrell RC, Gangolli SD (1984) Nitrosoproline formation in control and antibiotic-treated rats given nitrate and proline. Cancer Letters 25:231–235
Mansouri A (1979) Oxidation of human hemoglobin by sodium nitrite effect of β-93 thiolo groups. Biochem Biophys Res Commun 82:441–447
Mellet PO, Noel PR, Goutefongea R (1986) Nitrite-tryptophan reaction: Evidence for an equilibrium between tryptophan and its nitrosated form. J Agric Fd Chem 34:892–895
Nałecz MJ, Wojtczak L (1982) Surface charge of biological membranes and its regulatory functions. Post Biochem 28:191–225
Olson JA, Bridges CDB, Paeker L, Chytil F, Wolf G (1983) The function of vitamin A. Federat Proc 42:2740–2746
Podolak-Majczak M, Tyburczyk W (1986) Effect of joint action of sodium nitrite and carbaryl on rats organism. Part 4. Hepatotoxic action. Bromat Chem Toksykol 19:161–166
Pugh DL, Garner BB (1963) Reaction of carotene with nitrite solutions. J Agric Fd Chem 11:528–529
Reddy BS (1972) Studies on the mechanism of calcium and magnesium absorption in germfree rats. Arch Biochem Biophys 149:15–21
Roe JH, Rice EW (1948) A photometric method for the determination of free pentoses in animal tissues. J Biol Chem 173:507–512
Roels OA, Anderson OR (1969) Vitamin A and membranes. Am J Clin Nutr 22:1020–1032
Shuval HI, Gruener N (1977) Infant methemoglobinemia and other health effects of nitrates in drinking water. Prog Wat Tech 8:183–193
Ström G (1949) Influence of anoxia on lactate utilization in man after prolonged muscular work. Acta Physiol Scand 17:440–451
Strosznajder J (1978) The role of phospholipids in the permeability of membranes. Post Biol Kom 5:1–16
Tyburczyk W, Borkowska J, Klimek K, Galicki D (1989) Effect of combined action of sodium nitrite and phenitrotione on certain biochemical parameters in rat blood. Roczn PZH 40:58–64
Umbreit WW, Burris RH, Stanffer JF (1959) Manometric techniques. Burgess Publishing Co, USA
Urbanek-Karlowska B, Fonberg-Broczek B (1986) Effect of sodium nitrite and amidopyrine administration on hepatic level of nucleic acids in the rat. Roczn PZH 37:228–234
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Grudziński, I., Szymański, A. The effect of subchronic poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats. Arch. Environ. Contam. Toxicol. 21, 447–452 (1991). https://doi.org/10.1007/BF01060369
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DOI: https://doi.org/10.1007/BF01060369