Abstract
Estimates of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) body-burden acquired from an environment in which 2,3,7,8-TCDD has been introduced in a high concentration, are derived from an idealized linear reaction kinetic model. The model parameters are the 2,3,7,8-TCDD transfer factor from the environmental soil medium to the human body, the background intake, the soil concentration and the body and soil elimination half-times. Values of the transfer factor are estimated from reported human and environmental data. The model conservatively determines a time-scale over which the acquired body-burden may be significantly higher than the background dose caused by the ubiquitous presence of 2,3,7,8-TCDD in food, consumer products, etc. and allows comparison of the cumulative body-burden with published values for the minimum toxic dose and derived values of the minimum guideline dose. The linear nature of the model also provides a framework for the estimation of the 2,3,7,8-TCDD toxic equivalent (TEQ) body-burden acquired from environments in which a mixture of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are present.
Similar content being viewed by others
References
Abramovitz M, Stegun IA (1972) Handbook of mathematical functions. Dover, NY
Chementator (1991) New dioxin model reveals lower risk. Chemical Engineering. 98:21
Courant R, Hilbert D (1937) Methods of mathematical physics. Interscience, NY
Craig TO, Grzonka RB (1991) Persistent land contamination from the operation and subsequent fire destruction of a solvent recovery plant. (To be published)
Crosby DG, Wong AS (1977) Environmental degradation of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD). Science 195:1337–1338
Department of the Environment (1989) Dioxins in the environment, Report of an Interdepartmental Working Group on Polychlorinated Dibenzo-para-dioxins (PCDDs) and Polychlorinated Dibenzofurans (PCDFs), Pollution Paper No. 27. Her Majesty's Stationery Office, London
Manz A (1990) Cited in Chemical Engineering, October 1990. p 27
Moore WJ (1956). Physical chemistry. Longmans, London. p 539
Paustenbach DJ (1986) A critical examination of assumptions used in risk assessments of dioxin contaminated soil. Regulatory Toxicol Pharmacol 6:284–307
Pirkle JL, Wolfe WH, Patterson DG, Needham LL, Michalek JE, Miner JC, Peterson MR, Phillips DL (1989) Estimates of the Half-life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand. J Toxicol Environ Health 27:165–171
Podoll RT, Jaber HM, Mill T (1986) Tetrachlorodibenzodioxin: Rates of volatilization and photolysis in the environment. Environ Sci Technol 20:490–492
Poiger H, Schlatter C (1980). Influence of solvents and adsorbents on dermal and intestinal absorption of TCDD. Food Cosmetics Toxicol 18:477–481
Skene SA, Dewhurst IC, Greenberg M (1989). Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans: The risks to human health, a review. Human Toxicol 8:173–203
Somogyl A (1990) Cited in European Chemical News, 29th January 1990, p 18
Stevens KM (1981) Agent orange toxicity: A quantitative perspective. Human Toxicol 1:31–39
Travis CC, Hattemer-Frey HA (1988) Assessing the extent of human exposure to organics, In: Travis CC (ed) Carcinogen risk assessment. Plenum, NY, 70 pp
Umbreit TH, Hesse EJ, Gallo MA (1986) Bioavailability of dioxin in soil from a 2,4,5-T manufacturing site. Science 232:497–499
USEPA (United States Environmental Protection Agency) (1988). A cancer risk: specific dose estimate for 2,3,7,8-TCDD. Washington, DC
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Craig, T.O., Grzonka, R.B. A time-dependent 2,3,7,8-tetrachlorodibenzo-p-dioxin body-burden model. Arch. Environ. Contam. Toxicol. 21, 438–446 (1991). https://doi.org/10.1007/BF01060368
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01060368