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Models of ARA-C chemotherapy of L1210 leukemia in mice

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The results of clinical treatment of the L1210 mouse leukemia with cytosine arabinoside have been modeled with a direct action exponential growth model. Experimental growth kinetic and pharmacokinetic data were used to evaluate portions of the model. The data from a single in vivodrug-cancer cell interaction experiment have been used to determine the interaction coefficients. The model has then been used to simulate the results of various treatment schedules of the drug on the cancer system, with rather good agreement with experimental data.

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Himmelstein, K.J., Bischoff, K.B. Models of ARA-C chemotherapy of L1210 leukemia in mice. Journal of Pharmacokinetics and Biopharmaceutics 1, 69–81 (1973).

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