Abstract
The effectiveness and rapidity of drug absorption after its administration by an autoinjector was studied in normal male adults. In 12 who received pralidoxime chloride (600 mg) by an autoinjector and by needle and syringe, the plasma concentration of oxime was 82 % higher at 3 min after autoinjector administration, and a therapeutic plasma concentration (4 μg/ml) was attained in about 70% of the time required after needle- and- syringe administration. Atropine given to six subjects by both methods produced tachycardia faster and the time of maximal tachycardia was sooner after autoinjector administration. It is theorized that faster drug absorption occurs because the autoinjector “sprays” the drug through tissue.
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Sidell, F.R., Markis, J.E., Groff, W. et al. Enhancement of drug absorption after administration by an automatic injector. Journal of Pharmacokinetics and Biopharmaceutics 2, 197–210 (1974). https://doi.org/10.1007/BF01059762
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DOI: https://doi.org/10.1007/BF01059762