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Blood and salivary concentrations of sulfamethoxazole and trimethoprim in man

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Abstract

Saliva/blood and saliva/plasma concentration ratios were determined for sulfamethoxazole and trimethoprim following oral administration of cotrimoxazole to healthy human subjects. The mean experimentally determined saliva/plasma concentration ratios for sulfamethoxazole and trimethoprim were 0.0157 and 1.13, respectively. These values were shown to be in reasonable agreement with theoretical predictions. It was demonstrated that partitioning of drugs from saliva into the buccal must be considered in making theoretical predictions.

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Author notes

  1. R. Pocelinko

    Present address: USV Pharmaceutical Corp., 10707, Tuckahoe, New York

Authors and Affiliations

  1. Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., 07110, Nutley, New Jersey

    F. B. Eatman, A. C. Maggio, H. G. Boxenbaum, K. A. Geitner, W. Glover, T. Macasieb, A. Holazo, R. E. Weinfeld & S. A. Kaplan

  2. Special Treatment Unit, Newark Beth Israel Medical Center, 07112, Newark, New Jersey

    R. Pocelinko

Authors
  1. F. B. Eatman
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  2. A. C. Maggio
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  3. R. Pocelinko
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  4. H. G. Boxenbaum
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  5. K. A. Geitner
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  6. W. Glover
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  7. T. Macasieb
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  8. A. Holazo
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  9. R. E. Weinfeld
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  10. S. A. Kaplan
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Eatman, F.B., Maggio, A.C., Pocelinko, R. et al. Blood and salivary concentrations of sulfamethoxazole and trimethoprim in man. Journal of Pharmacokinetics and Biopharmaceutics 5, 615–624 (1977). https://doi.org/10.1007/BF01059687

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  • DOI: https://doi.org/10.1007/BF01059687

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