Journal of Pharmacokinetics and Biopharmaceutics

, Volume 14, Issue 5, pp 523–537 | Cite as

Implementation and evaluation of control strategies for individualizing dosage regimens, with application to the aminoglycoside antibiotics

  • Darryl Katz
  • David Z. D'Argenio


Three strategies are implemented for controlling serum concentrations by determining individualized dosage regimens. The methods incorporate, respectively, nonlinear least squares parameter estimation, Bayesian maximum a posterioriprobability estimation, and a stochastic control procedure that minimizes the expected value of an appropriate therapeutic cost. The performance of the three dose regimen calculation strategies was evaluated using Monte Carlo simulations of a typical therapeutic protocol for tobramycin.

Key words

stochastic control dosage regimen least squares Bayes' theorem Monte Carlo simulation 


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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Darryl Katz
    • 1
  • David Z. D'Argenio
    • 2
  1. 1.Department of MathematicsCalifornia State University at FullertonFullerton
  2. 2.Department of Biomedical EngineeringUniversity of Southern CaliforniaLos Angeles

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