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Comments on mean residence time determination

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Abstract

In a recent paper, D. O. Chanter challenged the applicability of the use of statistical moments in estimating mean residence time and proposed an alternative approach. Errors in that paper are pointed out which involve the improper equating of wholebody amount of drug with plasma amount of drug in a kinetic system. The theory for the two methods discussed by Chanter is presented in a pharmacokinetic context.

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References

  1. D. O. Chanter. The determination of mean residence time using statistical moments: Is it correct?J. Pharmacokin. Biopharm. 13:93–100 (1985).

    Article  CAS  Google Scholar 

  2. P. Meier and K. L. Zierler. On the theory of the indicator-dilution method for measurement of blood flow and volume.J. Appl. Physiol. 12:731–744 (1954).

    Google Scholar 

  3. W. Perl and P. Samuel. Input-output analysis for total input rate and total traced mass of body cholesterol in man.Circ. Res. 25:191–199 (1969).

    Article  CAS  PubMed  Google Scholar 

  4. L. Z. Benet and R. L. Galeazzi. Noncompartmental determination of the steady-state volume of distribution.J. Pharm. Sci. 68:1071–1074 (1979).

    Article  CAS  PubMed  Google Scholar 

  5. J. J. DiStefano III. Noncompartmental vs. compartmental analysis: Some bases for choice.Am. J. Physiol. 243 (Regulatory Integrative Comp. Physiol. 12):R1-R6 (1982).

    PubMed  Google Scholar 

  6. P. S. Collier. Some considerations on the estimation of steady state apparent volume of distribution and the relationships between volume terms.J. Pharmacokin. Biopharm. 11:93–105 (1983).

    Article  CAS  Google Scholar 

  7. N. A. Lassen and W. Perl,Tracer Kinetic Methods in Medical Physiology, Raven Press, New York, 1979, pp. 40–88.

    Google Scholar 

  8. J. J. DiStefano III and E. M. Landaw. Multiexponential, multicompartmental, and noncorapartmental modeling. I. Methodological limitations and physiological interpretations.Am. J. Physiol. 246(Regulatory Integrative Comp. Physiol. 15):R651-R664 (1984).

    PubMed  Google Scholar 

  9. D. G. Covell, M. Berman, and C. DeLisi. Mean residence time—Theoretical development, experimental determination, and practical use in tracer analysis.Math. Biosci. 72:213–244 (1984).

    Article  Google Scholar 

  10. K. L. Zierler. Equations for measuring blood flow by external monitoring of radioisotopes.Circ. Res. 16:309–321 (1965).

    Article  CAS  PubMed  Google Scholar 

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Landaw, E.M., Katz, D. Comments on mean residence time determination. Journal of Pharmacokinetics and Biopharmaceutics 13, 543–547 (1985). https://doi.org/10.1007/BF01059335

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  • DOI: https://doi.org/10.1007/BF01059335

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