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Effects of insecticides on the metal-activated hydrolysis of adenosine triphosphate by bluegill liver mitochondria

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Abstract

Investigations were made on the effects of the pesticides aldrin, 1 carbofuran, chlordane, DDE, Dasanit®, diazinon, dieldrin, endrin, heptachlor, Kepone®, lindane, malathion, methoxychlor, parathion, Thimet®, Sevin®, and toxaphene on the metal-ion-activated hydrolysis of adenosine triphosphate (ATP) by bluegill (Lepomis macrochirus Raf.) liver mitochondria. Chlordane, dieldrin, heptachlor, Kepone, lindane, methoxychlor, and toxaphene decreased the activities of Cd2+ and Zn2+ ATPases. Aldrin decreased Zn2+ ATPase but did not alter Cd2+ ATPase. The effects of endrin, diazinon, malathion, carbaryl, Thimet, Dasanit, and carbofuran on Cd2+ and Zn2+ ATPases were not investigated. DDE, dieldrin, lindane, parathion, and Thimet increased Mn2+ ATPase activity, whereas aldrin, heptachlor, and Kepone reduced Mn2+ ATPase activity. Dieldrin, lindane, toxaphene, diazinon, and parathion increased, whereas aldrin, endrin, heptachlor, Kepone, carbofuran, and Sevin decreased Mg2+ ATPase activity. DDE, toxaphene, diazinon, malathion, and parathion increased, but chlordane and endrin reduced Ca2+ ATPase activity.

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References

  • Ames, P. S.: DDT residues in the eggs of the osprey in the north-eastern United States and their relation to nesting success. J. Appl. Ecol. Suppl.3, 87 (1966).

    Google Scholar 

  • Anderson, A., R. March, and R. L. Metcalf: Inhibition of the succinic oxidase system of susceptible and resistant house flies by DDT and related compounds. Ann. Entomol. Soc.47, 595 (1954).

    Google Scholar 

  • Avi-dor, Y., and O. Gonda: Studies on the adenosine triphosphate-phosphate exchange and the hydrolysis of adenosine triphosphate catalyzed by a particulate fraction from the mosquito. Biochem. J.72, 8 (1959).

    PubMed  Google Scholar 

  • Bratkowski, T. A., and F. Matsumura: Properties of a brain adenosine triphosphate sensitive to DDT. J. Econ. Entomol.65, 1238 (1972).

    PubMed  Google Scholar 

  • Burdick, G. E., E. J. Harris, H. J. Dean, T. M. Walker, J. Shea, and D. Colby: The accumulation of DDT in lake trout and the effect on reproduction. Trans. Am. Fish. Soc.93, 127 (1964).

    Google Scholar 

  • Cheng, E. Y., and L. K. Cutkomp: The sensitivity of mitochondrial Mg2+ ATPase to DDT and analogs at different temperatures. Pest. Biochem. Physiol.7, 360 (1977).

    Google Scholar 

  • Colvin, H. J., and A. T. Philips: Inhibition of electron transport enzymes and cholinesterases by endrin. Bull. Environ. Contam. Toxicol.3, 106 (1968).

    Google Scholar 

  • Cooke, A. S.: Shell thinning in avian eggs by environmental pollutants. Environ. Pollut.4, 85 (1973).

    Google Scholar 

  • Cutkomp, L. K., H. H. Yap, E. Y. Cheng, and R. B. Koch: ATPase activity in fish tissue homogenates and inhibitory effects of DDT and related compounds. Chem.-Biol. Inter.3, 439 (1971a).

    Google Scholar 

  • —,—: Inhibition of oligomycin-sensitive (mitochondrial) Mg2+-ATPase by DDT and selected analogs in fish and insect tissue. Life Sci.10(2), 1201 (1971b).

    Google Scholar 

  • —: Thein vitro sensitivity of fish brain ATPases to organochlorine acaricides. Life Sci.11(2), 1123 (1972).

    Google Scholar 

  • —, —: Thein vivo sensitivity of ATPases to DDT, DDE, and physical immobilization in American cockroaches. Pest. Biochem. Physiol.6, 203 (1976).

    Google Scholar 

  • -, R. B. Koch, and D. Desaiah: Inhibition of ATPases by chlorinated hydrocarbons. In J. R. Coats (ed.): Insecticidal modes of action. New York: Academic Press (in press). (Not seen, but mentioned in a personal communication from L. K. Cutkomp).

  • Danneel, R.: Die giftwikung des rotenons und seinen derivative auf fische. III. Der angriffspunkt der gifte. Zeti. vergl. Physiol.18, 524 (1933).

    Google Scholar 

  • Davis, P. W., and G.W. Wedemeyer: Na+, K+ activated-ATPase inhibition in rainbow trout: a site for organochlorine pesticide toxicity. Comp. Biochem. Physiol.40B, 823 (1971).

    Google Scholar 

  • Desaiah, D., L. K. Cutkomp, and R. B. Koch: A comparison of DDT and its biodegradable analogs tested on ATPase enzymes in cockroach. Pest. Biochem. Physiol.4, 232 (1974).

    Google Scholar 

  • —, —, —: DDT: Effect of continuous exposure on ATPase activity in fish,Pimephale's promelas. Arch. Environ. Contam. Toxicol.3, 132 (1975).

    PubMed  Google Scholar 

  • Doherty, J. D., and F. Matsumura: DDT effects on certain ATP related systems in the peripheral nervous system of the lobster,Homarus americanus. Pest. Biochem. Physiol.5, 242 (1975).

    Google Scholar 

  • Ela, R., W. Chefurka, and J. R. Robinson: Invivo metabolism in the normal and poisoned cockroach,Periplanta americana. J. Insect Physiol.16, 2137 (1970).

    PubMed  Google Scholar 

  • Gonda, O., A. Traub, and Y. Avi-dor: The oxidative activity of particulate fractions from mosquitoes. Biochem. J.67, 487 (1957).

    PubMed  Google Scholar 

  • —: Effect of 1∶1∶1-trichloro-2∶2-di(p-chlorophenyl)ethane (DDT) and related compounds on the adenosine triphosphate-phosphate exchanges catalyzed by a particulate fraction from the mosquito. Biochem. J.73, 583 (1959).

    PubMed  Google Scholar 

  • Gregg, C. T., J. R. Johnson, C. R. Heisler, and L. F. Remmert: Inhibition of oxidative phosphorylation and related reactions in insect mitochondria. Biochem. et Biophys. Acta82, 343 (1964).

    Google Scholar 

  • Harvey, O., and A. W. A. Brown: The effect of insecticides on the rate of oxygen consumptionin Blatella. Can. J. Zool.29, 52 (1951).

    Google Scholar 

  • Henderson, C., Q. H. Pickering, and C. M. Tarzwell: Relative toxicity of the chlorinated hydrocarbon insecticides to four species of fish. Trans. Am. Fish. Soc.88, 23 (1959).

    Google Scholar 

  • Hickey, J. J., and D. W. Anderson: Chlorinated hydrocarbons and eggshell changes in raptorial and fish-eating birds. Science162, 271 (1968).

    PubMed  Google Scholar 

  • Hiltibran, R. C.: Oxidation of succinate by bluegill liver mitochondria. Trans. III. Acad. Sci.58, 176 (1965).

    Google Scholar 

  • —: Hydrolysis of adenosinetriphosphate by bluegill liver mitochondria. Trans. III. Acad. Sci.59, 249 (1966).

    Google Scholar 

  • —: Oxidation of alpha-ketoglutarate by bluegill liver mitochondria. Trans. III. Acad. Sci.60 (3), 244 (1967).

    Google Scholar 

  • —: The hydrolysis of adenosine triphosphate by bluegill liver mitochondria in the presence of 2,4-dichlorophenoxyacetic acid derivatives. Trans. III. Acad. Sci.62, 36 (1969a).

    Google Scholar 

  • —: Oxygen and phosphate metabolism of bluegill liver mitochondria in the presence of 2,4-dichlorophenoxyacetic acid derivatives. Trans. III. Acad. Sci.62, 175 (1969b).

    Google Scholar 

  • —: A proposed mechanism of the toxic action of DDT. Trans. III. Acad. Sci.64, 46 (1971a).

    Google Scholar 

  • —: Effects of cadmium, zinc, manganese, and calcium on oxygen and phosphate metabolism of bluegill liver mitochondria. J. Water Poll. Cont. Fed.43, 818 (1971b).

    Google Scholar 

  • —: The hydrolysis of adenosine triphosphate by bluegill liver mitochondria in the presence of 2,4,5-T and silvex derivatives. Trans. III. Acad. Sci.65, 51 (1972).

    Google Scholar 

  • —: Oxygen and phosphate uptake by bluegill liver mitochondria in the presence of some insecticides. Trans. III. Acad. Sci.74, 228 (1974).

    Google Scholar 

  • —: Oxygen and phosphate metabolism of bluegill liver mitochondria in the presence of some pesticides. Environmental Quality and Safety Supplement, vol. III (Coulston and Korte, eds.), Stuttgart: Georg Thieme Publishers. (1975).

    Google Scholar 

  • -Hiltibran, R. C.: Responses of bluegill liver mitochondria to herbicides, In E. O. Gangstad (ed.): Weed control methods for recreation facilities management. Boca Raton: CRC Press (in press).

  • —: The effect of rotenone on oxygen uptake by liver mitochondria of the bluegill,Lepomis macrochirus. Trans. III. Acad. Sci.58, 140 (1965).

    Google Scholar 

  • Holden, A. V.: Contamination of freshwater by persistent insecticides and their effects on fish. Ann. Appl. Biol.55, 332 (1965).

    Google Scholar 

  • Huner, W., B. F. Dowden, and J. J. Bennett: The effects of endrin on the oxygen consumption of the bluegill sunfish,Lepomis macrochirus. Proc. Louis. Acad. Sci.30, 80 (1967).

    Google Scholar 

  • Jackson, D. A., and D. R. Gardner: The effects of some organochlorine pesticide analogs on salmonid brain ATPases. Pestic. Biochem. Physiol.2, 377 (1973).

    Google Scholar 

  • —, —:In vitro effects of DDT analogs on trout brain Mg2+-ATPases, I. Specificity and physiological significance. Pestic. Biochem. Physiol.8, 113 (1978).

    Google Scholar 

  • Jandorf, B. J., H. B. Sarett, and O. Bodansky: Effect of oral administration of DDT on the metabolism of glucose and pyruvic acid in rat tissues. J. Pharmacol. Exp. Therap.88, 333 (1946).

    Google Scholar 

  • Johnson, D. W.: Pesticides and fishes-a review of selected literature. Trans. Am. Fish. Soc.97, 398 (1968).

    Google Scholar 

  • Johnston, C.: Thein vitro effect of DDT and related compounds on the succinic oxidase system of rat heart. Arch. Biochem.31, 375 (1951).

    PubMed  Google Scholar 

  • Kacew, S., R. L. Singhal, and G. M. Ling: DDT-induced stimulation of key gluconeogenic enzymes in rat kidney cortex. Can. J. Biochem.50, 225 (1972).

    PubMed  Google Scholar 

  • Kahn, H. M., and K. L. Cutkomp:In vitro studies of DDT, DDE, and ATPase as related to eggshell thinning. Arch. Environ. Contam. Toxicol.5, 627 (1982).

    Google Scholar 

  • Koch, R. B.: Inhibition of animal tissue ATPase activities by chlorinated hydrocarbon pesticides. Chem.-Biol. Inter.1, 199 (1969/70).

    Google Scholar 

  • —: Chlorinated hydrocarbon insecticide inhibition of cockroach and honey bee ATPases. Life Sci.8(2), 289 (1969).

    PubMed  Google Scholar 

  • —, —: Inhibition of oligomycin sensitive and insensitive adenosine triphosphate activity by chlorinated hydrocarbon insecticides. Biochem. Pharmacol.20, 3243 (1971).

    PubMed  Google Scholar 

  • Lehninger, A. L.: Biochemistry, 2 ed. New York: Worth Publishing (1975).

    Google Scholar 

  • —: Energy-linked ion movements in mitochondrial systems. Adv. Enzym.29, 259 (1967).

    Google Scholar 

  • Lindahl, P. E., and K. E. Oberg: The effect of rotenone on respiration and its point of attack. Exp. Cell. Res.23, 228 (1961).

    PubMed  Google Scholar 

  • Lowry, O. H., and J. A. Lopez: The determination of inorganic phosphate in the presence of labile phosphate esters. J. Biol. Chem.162, 421 (1946).

    Google Scholar 

  • Matsumura, F., and K. C. Patil: Adenosine triphosphatase sensitive to DDT in synapse of rat brain. Science166, 121 (1969).

    PubMed  Google Scholar 

  • Metcalf, R. L.: Organic insecticides, their chemistry and mode of action. New York: Interscience Publishers (1957).

    Google Scholar 

  • Morrison, P. E., and A. W. A. Brown: The effect of insecticides on cytochrome oxidase obtained from the American cockroach. J. Econ. Entomol.47, 723 (1954).

    Google Scholar 

  • Mount, D. I: Chronic effects of endrin on bluntnose minnows and guppies. U.S. Fish Wildl. Serv. Res. Rept. 58 (1962).

  • O'Brien, R. D.: Insecticides: Action and metabolism. New York: Academic Press (1967).

    Google Scholar 

  • Pardini, R. S., J. C. Heidker, and B. Payne: The effect of some chlorine pesticides, benzenehexachloride and toxaphene on mitochondrial electron transport. Bull. Environ. Contam. Toxicol.6, 436 (1971).

    PubMed  Google Scholar 

  • Parker, V. H.: 1∶1∶1-trichloro-2∶2-di-(p-chlorophenyl)ethane (DDT) and rat adipose tissue. Biochem. J.77, 74 (1960).

    Google Scholar 

  • Pickering, Q. H., C. Henderson, and A. E. Lemke: The toxicity of organic phosphorus insecticides to different species of warm water fishes. Trans. Am. Fish. Soc.91, 175 (1962).

    Google Scholar 

  • Pimentel, D.: Ecological effect of pesticides on non-target species. Office of Science and Technology, Executive Office of the President, Washington, DC (1971).

    Google Scholar 

  • Porter, R. D., S. N. Wiemeyer: Dieldrin and DDT: Effects on sparrow hawk eggshells and reproduction. Science165, 99 (1969).

    Google Scholar 

  • Riedel, B., and G. Christensen: Effect of selected water toxicants and other chemicals upon adenosine triphosphate activityin vitro. Bull. Environ. Contam. Toxicol.23, 365 (1979).

    PubMed  Google Scholar 

  • Riker, W. F., V. R. Huebner, S. B. Raska, and M. Cattell: Studies on DDT 2,2-bi(parachlorophenyl)-l,l,l-trichloroethane. Effects on oxidative metabolism. J. Pharmacol. Exp. Therap.88, 327 (1946).

    Google Scholar 

  • Sacklin, J. A., L. C. Terriere, and L. F. Remmert: Effect of DDT on enzymatic oxidation and phosphorylation. Science122, 377 (1955).

    PubMed  Google Scholar 

  • Sacktor, B.: A comparison of the cytochrome oxidase activity of two strains of house flies. J. Econ. Entomol.43, 832 (1950).

    Google Scholar 

  • Tischler, N.: Studies of how derris kills insects. J. Econ. Entomol.28, 215 (1935).

    Google Scholar 

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  1. State Natural History Survey Division, Natural Resources Building, Illinois Institute of Natural Resources, 607 E. Peabody, 61820, Champaign, Illinois

    Robert C. Hiltibran

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Hiltibran, R.C. Effects of insecticides on the metal-activated hydrolysis of adenosine triphosphate by bluegill liver mitochondria. Arch. Environ. Contam. Toxicol. 11, 709–717 (1982). https://doi.org/10.1007/BF01059159

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