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Steady-state moxalactam pharmacokinetics in patients: Noncompartmental versus two-compartmental analysis

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Abstract

Moxalactam pharmacokinetics at steady state was examined in a group of 40 patients with presumed or proven abdominal sepsis. Mean steady-state serum concentrations ranged from 27.0 to 211.0 mcg/ml and correlated inversely with creatinine clearance (r=0.91, p<0.0001). Terminal half-life ranged from 1.27 to 8.27 hr and reflected the varying renal function of the patients. Moxalactam total body clearance (CL)displayed excellent correlation with creatinine clearance as 92%(r 2×100)of the variance in clearance could be accounted for by renal function (p< 0.0001). Pharmacokinetic parameters were estimated using noncompartmental analysis based on statistical moment theory. Noncompartmentally determined CLwas in agreement with CLdetermined by nonlinear least squares regression (r=0.99, p< 0.0001).Moxalactam total body clearance is best predicted from creatinine clearance corrected for body surface area.

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, 14260, Buffalo, New York

    Douglas J. Swanson, Donald P. Reitberg & Jerome J. Schentag

  2. Departrnent of Surgery, Millard Fillmore Hospital, 14209, Buffalo, New York

    Philip B. Wels

  3. Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, 14209, Buffalo, New York

    Douglas J. Swanson, Donald P. Reitberg, Ian L. Smith & Jerome J. Schentag

Authors
  1. Douglas J. Swanson
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  2. Donald P. Reitberg
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  3. Ian L. Smith
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  4. Philip B. Wels
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  5. Jerome J. Schentag
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Additional information

Supported by a grant from Eli Lilly Company and in part by NIGMS Grant 20852 from the National Institutes of Health.

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Swanson, D.J., Reitberg, D.P., Smith, I.L. et al. Steady-state moxalactam pharmacokinetics in patients: Noncompartmental versus two-compartmental analysis. Journal of Pharmacokinetics and Biopharmaceutics 11, 337–353 (1983). https://doi.org/10.1007/BF01058954

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  • DOI: https://doi.org/10.1007/BF01058954

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