Abstract
The distributions of radioactivity were examined by whole body autoradiography and liquid scintillation spectrophotometry in male ddY mice following oral administration of tritium-labelled Irgasan® DP300 (2,4,4′-trichloro-2′-hydroxydiphenyl ether) (I) and its three chlorinated derivatives; 2′,3,4,4′-tetrachloro-2-hydroxydiphenyl ether (II), 2′,4,4′,5-tetrachloro-2-hydroxydiphenyl ether (III) and 2′,3,4,4′,5-pentachloro-2-hydroxydiphenyl ether (IV). The autoradiograms at 6 or 24 hr showed that the radioactivity distributed in the gall, liver, lung, heart, and kidneys. Among these tissues the radioactivity was most concentrated in the gall, suggesting the enterohepatic circulation of these compounds. A much higher level of radioactivity in each tissue was observed in mice receiving [3H]-III than the other compounds tested. Most of the radioactivity disappeared from each tissue in 24 hr due to [3H]-Irgasan DP300, [3H]-II or [3H]-IV, but in 96 hr it was due to [3H]-III.
The cumulative radioactivity excreted in urine after administration of these compounds was in the order of [3H]-Irgasan DP300, [3H]-II, [3H]-IV and [3H]-III while that in feces was in the order of [3H]-IV, [3H]-III, [3H]-II and [3H]-Irgasan DP300,
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amemiya T, Sakai M, Mori K, Suzuki S, Kazama M (1984) Hygienic Chemical Studies on Household Necessities (XI). High Performance Liquid Chromatography of Irgasan® DP-300 and Thiabendazole Used as Sanitary Finishing Agent in Textile Products. Ann Rep Tokyo Metr Res Lab P H 35:133–137
Amemiya T, Sakai M, Ikeda K, Mori K, Suzuki S, Watanabe Y (1985) Hygienic Chemical Studies on Household Necessities (XVI). Dissolution Test of Irgasan® DP-300 and Thiabendazole Used as Sanitary Finishing Agent in Commercial Textile Products. Ann Rep Tokyo Metr Res Lab P H 36:123–128
Black JG, Howes D, Rutherford T (1975) Percutaneous absorption and metabolism of Irgasan® DP300. Toxicology 3:33–47
Chow AYK, Hirsch GH, Buttar HS (1977) Nephrotoxic and hepatotoxic effects of Triclosan and Chlorhexidine in rats. Toxicol Appl Pharmacol 42:1–10
Kanetoshi A, Ogawa H, Anetai M, Katsura E, Kaneshima H (1985) Studies on the chemicals used in household necessities. I. Analysis of antimicrobial agents in fabrics. Eisei Kagaku 31:245–250
Kanetoshi A, Ogawa H, Katsura E, Kaneshima H (1987) Chlorination of Irgasan® DP300 and formation of dioxins from its chlorinated derivatives. J Chromatogr 389:139–153
Lyman FL, Furia T (1969) Toxicology of 2,4,4′-trichloro-2′-hydroxydiphenyl ether. Indust Med 38:45–52
Nilsson C-A, Andersson K, Rappe C, Westermark S-O (1974) Chromatographic evidence for the formation of chlorodioxins from chloro-2-phenoxyphenols. J Chromatogr 96:137–147
Onodera S, Ogawa M, Suzuki S (1987) Chemical changes of organic compounds in chlorinated water. XIII. Gas chromatographic-mass spectrometric studies of the reactions of Irgasan® DP 300[5-chloro-2-(2,4-dichlorophenoxy)phenol] with chlorine in dilute aqueous solution. J Chromatogr 392:267–275
Tulp MThM, Sundström G, Martron LBJM, Hutzinger O (1979) Metabolism of chlorodiphenyl ethers and Irgasan® DP300. Xenobiotica 9:65–77
Yuge O (1983) The antimicrobial treatments for fabrics. J Antibact Antifung Agents 11:76–81
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kanetoshi, A., Ogawa, H., Katsura, E. et al. Disposition and excretion of Irgasan® DP300 and its chlorinated derivatives in mice. Arch. Environ. Contam. Toxicol. 17, 637–644 (1988). https://doi.org/10.1007/BF01055832
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01055832