Abstract
Previous studies from this laboratory have shown that α1proteinase inhibitor (α1-PI) can be inactivated by aldehydes found in the cigarette smoke as well as by industrial chemicals. Studies presented here demonstrate the synergistic inactivation of α1-PI by styrene oxide or 1,2-dichloroethane when mixed with acrolein or pyruvic aldehyde and vice-versa. The data suggest that smokers exposed to chemicals in industry may be more prone to lung emphysema due to synergistic inactivation of α1-PI by chemicals and cigarette smoke components.
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References
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Ansari, G.A.S., Gan, J.C. & Barton, B.K. Synergistic inactivation of plasma α1-proteinase inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2-dichloroethane. Arch. Environ. Contam. Toxicol. 17, 533–536 (1988). https://doi.org/10.1007/BF01055520
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DOI: https://doi.org/10.1007/BF01055520