Abstract
An investigation was undertaken on the accumulation of DDT and its metabolites in the rat. Rats received 14.5 mg DDT/kg b.w. every day for 52 days. Growth, food intake, body composition, and the activities of various enzymes were little affected. However, the level of total lipids fell 30% and the weight of the liver rose 20% due to cellular hypertrophy induced by the DDT. The quantity of DDT and its metabolites found in the carcass was 24 mg/rat i.e. three times that found in rats dead after a single dose of 200 mg/kg. Liver and brain contained 130 Μg/rat and 10 Μg/rat, respectively i.e. five times lower than those found in the rats which died from an acute dose of DDT. In the carcass,p,p′ DDT accumulates more thanp,p′ DDE orp,p′ DDD; the latter is preponderant in the liver.
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Mitjavila, S., Carrera, G., Boigegrain, R.A. et al. I. Evaluation of the toxic risk of DDT in the rat: During accumulation. Arch. Environ. Contam. Toxicol. 10, 459–469 (1981). https://doi.org/10.1007/BF01055442
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DOI: https://doi.org/10.1007/BF01055442