Abstract
Effects of thiamine, thiamine monophosphate (TMP), and thiamine diphosphate (TDP) on excitatory cholinergic and inhibitory noncholinergic nonadrenergic neuromuscular transmissions were studied in the smooth muscles of the gastric fundus and in the circular layer of the distal colon of the guinea pig, respectively. It was found that, when applied in the physiological concentration range, thiamine, TMP, and TDP evoked depolarization and an increase in strain in the smooth muscle strips, as well as an increase in the amplitude of inhibitory synaptic potentials and postinhibitory depolarization. The amplitude of the excitatory synaptic potentials increases in the presence of thiamine and TMP, and decreases in the presence of TDP. The results obtained suggest that thiamine and TMP, which are normally present in the extracellular medium, may modulate synaptic transmission, as well as the electrical and contractile activity of the smooth muscles in the gastrointestinal tract.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
R. E. Davis and G. C. Icke, “Clinical chemistry of thiamine,”Adv. Clin. Chem.,23, 93–140 (1983).
H. Iwata, “Possible role of thiamine in the nervous system,”Trends Pharm. Sci.,3, No. 4, 171–173 (1982).
J. P. Blass, “Vitamin and nutritional deficiencies,” in:Basic Neurochemistry. Molecular, Cellular and Medical Aspects, New York (1989), pp. 671–684.
L. Bettendorff, “Thiamine in excitable tissues: reflections on a non-cofactor role,”Metabol. Brain Dis.,9, No. 3, 183–209 (1994).
A. V. Romanenko, “Effect of thiamine on the synaptic junctions of different types,”Neirofiziologiya,18, No. 5, 621–629 (1986).
A. V. Romanenko, “A new way of muscle activity regulation: thiamine participation in neuromuscular transmission,” in:Muscle and Motility, Vol. 2, Hampshire (1990), pp. 151–153.
C. M. E. Tallaksen, T. Bohmer, H. Bell, and J. Karlsen, “Concomitant determination of thiamine and its phosphate esters in human blood and serum by high performance liquid chromatography,”J. Chromatogr.,564, 127–136 (1991).
M. J. Royer-Morrot, A. Zhiri, F. Paille, and R. J. Royer, “Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men,”Eur. J. Clin. Pharmacol.,42, 219–222 (1992).
W. Weber and H. Kewitr, “Determination of thiamine in human plasma and its pharmacokinetics,”Eur. J. Clin. Pharmacol.,28, 213–219 (1985).
T. Kawasaki, “Vitamin B1: Thiamine,” in:Modern Chromatographic Analysis of Vitamins, Marcel Dekker, Inc., New York (1992), p. 575.
L. Bettendorff, L. Weekers, P. Wins, and E. Schoffeniels, “Injection of sulbuthiamine induces an increase in thiamine triphosphate in rat tissues,”Biochem. Pharmacol.,40, 2557–2560 (1990).
G. Rindi, C. Partini, and M. Poloni, “Monophosphate, the only phosphoric ester of thiamine in the cerebro-spinal fluid,”Experientia,37, No. 9, 975–976 (1981).
D. P. Artemenko, V. A. Buryi, V. A. Vladimirova, and M. F. Shuba, “Modification of a single sucrose-gap technique,”Fiziol. Zh. SSSR,28, No. 3, 374–380 (1982).
A. V. Gurkovskaya, “Effect of temperature on spontaneous electrical and contractile activities of the portal vein smooth muscle cells,”Fiziol. Zh. SSSR,51, No. 5, 712–720 (1971).
R. A. R. Bywater, M. E. Holman, and G. S. Taylor, “Atropine resistance depolarization in the guinea-pig intestine,”J. Physiol.,316, July, 47–56 (1981).
I. A. Vladimirova, V. P. Zagorodnyuk, I. V. Ostrovskii, et al., “Specificity of the ultrasound-induced changes of the synaptic processes of different transmitter nature in smooth muscles,”Neirofiziologiya/Neurophysiology,1, No. 4, 297–301 (1993).
V. P. Zagorodnyuk, I. A. Vladimirova, M. F. Shuba, et al., “Selectivity in the morphine and ketamine effects on the neuromuscular transmissions of different types in smooth muscles of the stomach and colon of the guinea pig,”Neirofiziologiya/Neurophysiology,1, No. 3, 165–167 (1993).
V. P. Zagorodnyuk and C. A. Maggi, “Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon,”Br. J. Pharmacol.,112, 1077–1082 (1994).
V. P. Zagorodnyuk, P. Santicioli, and C. A. Maggi, “Different Ca2+ influx pathways mediate tachikinin receptor-induced contraction in circular muscle of guinea-pig colon,”Eur. J. Pharmacol.,255, 9–15 (1994).
M. F. Shuba and I. A. Vladimirova, “Effect of apamin on the electrical responses of smooth muscle to adenosine-5-triphosphate and non-adrenergic, non-cholinergic nerve stimulation,”Neuroscience,5, No. 5, 853–859 (1980).
I. A. Vladimirova and M. F. Shuba, “Synaptic processes in smooth muscles,”Neirofiziologiya,16, No. 3, 307–319 (1984).
A. V. Romanenko, “Effect of thiamine on neuromuscular transmission in the frog,”Neirofiziologiya,17, No. 6, 794–800 (1985).
A. V. Romanenko, V. B. Fenik, and O. M. Arsan, “Effect of thiamine on the rat skeletal muscle,”Fiziol. Zh. SSSR,37, No. 1, 35–41 (1991).
L. Waldenlind, L. Elfman, and B. Rydqvist, “Binding of thiamine to nicotinic acetylcholine receptor inTorpedo marmorata and the frog end plate,”Acta Physiol. Scand.,103, No. 2, 154–159 (1978).
K. I. Enomoto and C. Edwards, “Thiamine blockade of neuromuscular transmission,”Brain Res.,358, 316–323 (1985).
D. R. Doerge, M. G. McNamee, and L. L. Ingrahm, “Modification of acetylcholine receptor-mediated ion permeability by thiamine,”Mol. Pharmacol.,15, No. 3, 747–750 (1979).
D. R. Doerge, M. G. McNamee, and L. L. Ingrahm, “Some neurochemical properties of thiamine,”Ann. New York Acad. Sci.,378, 422–434 (1982).
A. I. Voskoboev and I. P. Chernikevich, “Depositing and proteidization of thiamine diphosphate in modelling of different forms of thiamine deficiency,” in:Metabolic Effects of the Functionally Bound B Vitamin Deficiency [in Russian], Moscow (1987) pp. 7–35.
S. K. Sharma and J. H. Quastel, “Transport and metabolism of thiamine in rat brain cortexin vitro,”Biochem. J.,94, No. 3, 790–800 (1965).
Y. Nose, A. Iwashima, and H. Nishino, “Thiamine uptake by rat brain slices,” in:Thiamine, New York (1976), pp. 157–168.
L. Bettendorff and P. Wins, “Mechanism of thiamine transport in neuroblastoma cells. Inhibition of a high affinity carrier by sodium channel activators and dependence of thiamine uptake on membrane potential and intracellular ATP,”J. Biol. Chem.,269, 14379–14385 (1994).
L. R. Johnson and C. J. Guber, “Studies on the physiological functions of thiamine. III. The phosphorylation of thiamine in brain,”J. Biol. Chem.,156, No. 1, 85–96 (1968).
J. W. Peterson, C. J. Gubler, and S. A. Kuby, “Partial purification and properties of thiamine pyrophosphokinase from pig brain,”Biochim. Biophys. Acta.,397, 377–394 (1975).
Yu. M. Ostrovskii,Active Centers and Groups in Thiamine Molecule [in Russian], Nauka i Tekhnika, Minsk (1975).
G. A. Kochetov,Thiamine Enzymes [in Russian], Nauka, Moscow (1978).
J. R. Cooper, R. H. Roth, and M. M. Kini, “Biochemical and physiological function of thiamine in nervous tissue,”Nature 199, No. 4893, 609–610 (1963).
Y. Itokawa and J. R. Cooper, “Ion movement and thiamine. II. The release of vitamin from membrane fragments,”Biochim. Biophys. Acta,196, No. 2, 274–284 (1970).
Y. Itokawa and J. R. Cooper, “Thiamine release from nerve membranes by tetrodotoxin,”Science,166, No. 3906, 759–761 (1969).
Author information
Authors and Affiliations
Additional information
Neirofiziologiya/Neurophysiology, Vol. 26, No. 6, pp. 449–457, November–December, 1994.
Rights and permissions
About this article
Cite this article
Romanenko, A.V., Gnatenko, V.M. & Vladimirova, I.A. Effect of thiamine on neuromuscular transmission in smooth muscles. Neurophysiology 26, 370–377 (1994). https://doi.org/10.1007/BF01053581
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01053581