Skip to main content
SpringerLink
Log in

Parkinson's disease and aging: Changes of somatosensory evoked potentials in humans

  • Published:
Neurophysiology Aims and scope

Abstract

Somatosensory evoked potentials (SSEP) elicited by electrical stimulation of the median nerve were compared in patients with Parkinson's disease and individuals without clinical manifestations of extrapyramidal insufficiency (46 and 55 persons, respectively). The amplitude of the N31 component was found to diminish in Parkinsonian patients while the latency of the P44 component increased significantly. In addition, these parameters depended on the age of the tested subjects; the direction of age-related changes of the N31 and P44 components coincided with those typical of parkinsonism. Our findings seem to suggest that changes in the somatic afferentation caused by Parkinson's disease and aging are of the same type and depend on disturbances in the nigrostriatal dopaminergic system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. R. Snider, S. Fahn, W. P. Isgreen, and L. J. Cote, “Primary sensory symptoms in parkinsonian patients,”Neurology,26, No. 2, 423–429 (1976).

    PubMed  Google Scholar 

  2. W. C. Koller, “Sensory symptoms in Parkinson's disease,”Neurology,34, No 5, 957–959 (1984).

    PubMed  Google Scholar 

  3. I. Bodis-Wollner, S. Mitra, P. Bobak, et al., “Low frequency distortion in spatio-temporal threshold surface in Parkinson's disease,”Invest. Opthalmol. Vision Sci.,25, Suppl., 313 (1984).

    Google Scholar 

  4. D. Regan and C. Maxner, “Orientation-selective visual loss in patients with parkinson's disease,”Brain,110, No. 2, 415–432 (1987).

    PubMed  Google Scholar 

  5. H. K. Chiappa,Parkinson's Disease, Evoked Potentials in Clinical Medicine, Raven Press, New York (1983).

    Google Scholar 

  6. Z. Grosswasser, A. Kriss, S. Dell, et al., “Pattern VEPs, SEPs and BAEPs in Parkinson's disease,”Electroencephalogr. Clin. Neurophysiol.,61, No. 2, 166 (1985).

    Google Scholar 

  7. J. Jorg and H. Gerhard, “Somatosensory, motor and special evoked potentials to single and double stimulation in ‘Parkinson's disease’: an early diagnostic test?,”J. Neural Transmiss. Gen. Sec.,25, Suppl., 81–88 (1987).

    Google Scholar 

  8. P. M. Rossini, F. Babiloni, G. Bernardi, et al., “Abnormalities of short-latency somatosensory evoked potentials in parkinsonian patients,”Electroencephalogr. Clin. Neurophysiol.,74, No. 3, 277–289 (1989).

    PubMed  Google Scholar 

  9. N. B. Man'kovskii, I. N. Karaban', and E. A. Myalovitskaya, “Central mechanisms of development of the motor disorders in aging humans,”Fiziol. Zh.,36, No. 5, 62–70 (1990).

    PubMed  Google Scholar 

  10. K. Nakashima, T. Nitta, and K. Takahashi, “Recovery functions of somatosensory evoked potentials in parkinsonian patients,”J. Neurol. Sci.,108, No. 1, 24–31 (1992).

    PubMed  Google Scholar 

  11. G. F. Lakin,Biometry [in Russian], Vysshaya Shkola, Moscow (1980).

    Google Scholar 

  12. V. A. Otellin and É. B. Arushanyan,The Nigrostriatal System [in Russian], Meditsina, Moscow (1989).

    Google Scholar 

  13. G. Chevalier and J. M. Deniau, “Disinhibition as a basic process in the expression of striatal functions,”TINS,13, No. 7, 277–280 (1990).

    PubMed  Google Scholar 

  14. G. Krauthamer and M. Dalsass, “Differential synaptic modulation of polysensory neurons of the intralaminar thalamus by medial and lateral caudate nucleus and substantia nigra,”Brain Res.,154, No. 1, 137–143 (1978).

    PubMed  Google Scholar 

  15. D. Albe-Fessard, P. Cesaro, and B. Hamon, “Effect of striatal stimulation on cellular activities of medial thalamic neurons studied in rats,”Exp. Brain Res.,50, No. 1, 34–44 (1983).

    PubMed  Google Scholar 

  16. L. P. Zenkov, and P. V. Mel'nichuk,Central Mechanisms of Afferentation in Humans [in Russian], Meditsina, Moscow (1985).

    Google Scholar 

  17. J. D. Reisine, J. Z. Fields, and H. I. Yamamura, “Neurotransmitter receptor alterations in Parkinson's disease,”Life Sci.,21, No. 2, 335–344 (1977).

    PubMed  Google Scholar 

  18. V. P. Barkhatova,Neurotransmitters and Extrapyramidal Pathology [in Russian], Meditsina, Moscow (1988).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine

    V. V. Garkavenko, M. Ya. Voloshin, L. I. Limanskaya & M. S. Podol'skii

  2. Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine

    I. N. Karaban' & M. S. Podol'skii

Authors
  1. V. V. Garkavenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. N. Karaban'
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Ya. Voloshin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. I. Limanskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. S. Podol'skii
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Neirofiziologiya/Neurophysiology, Vol. 26, No. 3, pp. 141–145, March–April, 1994.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Garkavenko, V.V., Karaban', I.N., Voloshin, M.Y. et al. Parkinson's disease and aging: Changes of somatosensory evoked potentials in humans. Neurophysiology 26, 114–118 (1994). https://doi.org/10.1007/BF01053088

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01053088

Keywords

Search

Navigation