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The role of structures of the ventrolateral medulla in cardiovascular regulation

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Neurophysiology Aims and scope

Abstract

Both optimum cardiac operating regime and the state of vascular tonus depend largely on the activity of chemically sensitive structures of the ventrolateral medulla.

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Literature cited

  1. S. V. Vereskun, A. V. Dmitrieva, and A. G. Kartseva, "Role of neurons of the cat caudal ventrolateral medulla in mechanisms governing cardio-hemodynamic response," Fiziol. Zh.,36, No. 3, 20–25 (1990).

    Google Scholar 

  2. A. A. Vishnevskii and B. I. Tkachenko, "Capacitance functions of the spleen during electrical stimulation of structures of the ventrolateral medulla," Byul. Eksp. Biol. Med.,109, No. 3, 213–215 (1990).

    Google Scholar 

  3. A. Kh. Kade, Function Organization of Central Sympathetic Influences on the Heart, Author's doctorate thesis, Kiev (1991).

  4. A. G. Kartseva, S. B. Vereskun, and A. V. Dmitrieva, "Study of cardiohemodynamic response produced by glycine action on neurons of the cat ventrolateral medulla," Fiziol. Zh.,34, No. 2, 40–46 (1988).

    Google Scholar 

  5. V. A. Kul'chitskii and B. I. Tkachenko, "Contribution of structures of the ventrolateral medulla to producing pressor vasomotor reflexes," Fiziol. Zh. SSSR,74, No. 10, 1409–1417 (1988).

    Google Scholar 

  6. V. A. Kul'chitskii, Organ Macro- and Microhemodynamics during Activation or Blockade of the Ventral Medulla, Author's doctorate thesis, Leningrad (1989).

  7. V. A. Kul'chitskii, "Fundamental and applied aspects of the physiology of the ventral medulla," Usp. Fiziol. Nauk,22, No. 3, 77–94, 1991.

    Google Scholar 

  8. V. P. Lebedev, A. V. Krasyukov, and C. A. Nikitin, "Significance of sympathoactivating structures of the bulbar ventrolateral surface in vasomotor regulation," Fiziol. Zh. SSSR,70, No. 8, 1221–1231 (1984).

    Google Scholar 

  9. L. N. Shapoval and L. S. Pobegailo, "Changes in efferent activity in the renal nerve and autonomic response to applying GABA to structures of the ventrolateral bulbar surface in cats," Neirofiziologiya,19, No. 3, 327–334 (1987).

    Google Scholar 

  10. L. N. Shapoval, Yu. M. Pelevin, and L. S. Pobegailo, "Ultrastructural organization of the chemically sensitive ventrolateral region of the feline medulla," Neirofiziologiya,21, No. 3, 300–305 (1989).

    Google Scholar 

  11. L. N. Shapoval, L. S. Pobegailo, and V. F. Sagach, "GABA-ergic mechanisms of regulating vascular tonus and cardiac activity located in the caudal ventrolateral region of the cat medulla," Neirofiziologiya,23, No. 6, 698–703 (1991).

    Google Scholar 

  12. L. N. Shapoval, L. S. Pobegailo, and V. F. Sakach, "Study of cardio- and hemodynamic response to GABA application to neuronal structures of the ventrolateral medulla in cats," Fiziol. Zh.,37, No. 1, 18–24 (1991).

    Google Scholar 

  13. L. N. Shapoval, V. F. Sagach, and L. S. Pobegailo, "Chemosensitive ventrolateral medulla in the cat: the fine structure and GABA-induced cardiovascular effects," J. Auton. Nervn. Syst.,36, No. 1, 159–172 (1991).

    Google Scholar 

  14. S. K. Agarwal, A. J. Gelsema, and F. R. Calaresu, "Neurons in rostral VLM are inhibited by chemical stimulation of caudal VLM in rats," Am. J. Physiol.,257, No. 2, R265-R270 (1989).

    Google Scholar 

  15. S. K. Agarwal and F. R. Calaresu, "Reciprocal connections between nucleus tractus solitarii and rostral ventrolateral medulla," Brain Res.,523, No. 1, 305–308 (1990).

    Google Scholar 

  16. K. Amendt, J. Czachurski, K. Dembovski, and H. Seller, "Bulbospinal projections to the intermediolateral cell column; a neuroanatomical study," J. Auton. Nervn. Syst.,1, No. 1, 103–107 (1979).

    Google Scholar 

  17. J. A. Andrezik, V. Chan-Palay, and S. L. Palay, "The nucleus paragigantocellularis laterals in the rat: demonstration of afferents by the retrograde transport of horseradish peroxidase," Anat. Embryol.,161, No. 2, 373–390 (1981).

    Google Scholar 

  18. D. M. Armstrong, C. A. Ross, V. M. Pickel,et al., "Distribution of dopamine, noradrenaline and adrenaline-containing bodies in the rat medulla oblongata demonstrated by immunocytochemical localization of catecholamine biosynthetic enzymes," J. Comp. Neurol.,212, No. 1, 173–187 (1982).

    Google Scholar 

  19. S. P. Arneric, C. R. Kelley, and F. D. Tingley, "Release of 3H-ACH and endogenous glutamate in the rostral ventrolateral medulla (RVM): effects of clonidine," FASEB J.,3, No. 3, A232 (1989).

  20. S. P. Arneric, R. Giuliano, P. Ernsberger,et al., "Synthesis, release and receptor binding of acetylcholine in the CL area of the rostral ventrolateral medulla: contribution in regulating arterial pressure," Brain Res.,511, No. 1, 98–112 (1990).

    Google Scholar 

  21. Ph. E. Aylward, J. M. Elliot, R. J. McRitchie, et al., "Cardiac performance in the conscious rabbit with acute hypertension following brainstem lesions coinciding with the A1 group of catecholamine neurons," Hypertension,2, No. 4, 379–386 (1984).

    Google Scholar 

  22. S. M. Barman and G. L. Gebber, "Lateral tegmental field neurons of cat medulla: a source of basal activity of ventrolateral medullospinal sympathoexciting neurons," J. Neurophysiol.,57, No. 5, 1410–1424 (1987).

    Google Scholar 

  23. S. M. Barman and G. L. Gebber, "Axonal projections patterns of ventrolateral medullospinal sympathoexcitatory neurons," J. Neurophysiol.,53, No. 6, 1551–1566 (1985).

    Google Scholar 

  24. R. M. Bauer, G. A. Iwamoto, and T. G. Waldrop, "Ventrolateral medullary neurons modulate pressor reflex to muscular contraction," Am. J. Physiol.,257, No. 5, R1154-R1161 (1989).

    Google Scholar 

  25. E. E. Benarroch, A. R. Granata, R. Giuliano, and D. J. Reis, "Neurons of the C1 area of rostral ventrolateral medulla mediate nucleus tractus solitarii hypertension," Hypertension,8, No. 4, Pt. 2, 56–60 (1986).

    Google Scholar 

  26. E. E. Benarroch, A. R. Granata, D. A. Ruggiero,et al., "Neurons of C1 area mediate cardiovascular responses initiated from ventral medullary surface," Am. J. Physiol.,250, No. 5, Pt. 2, R932-R945 (1986).

    Google Scholar 

  27. W. W. Blessing, A. K. Goodchild, R. A. L. Dampney, and J. P. Chalmers, "Cell groups in the lower brain stem of the rabbit projecting to the spinal cord, with special reference to catecholamine-containing neurons," Brain Res.,221, No. 1, 35 (1981).

    Google Scholar 

  28. W. W. Blessing and D. J. Reis, "Inhibitory cardiovascular function of neurons in the caudal ventrolateral medulla of the rabbit: relationship to the area containing A1 noradrenergic cells," Brain Res.,253, No. 1, 161–171 (1982).

    Google Scholar 

  29. W. W. Blessing and J. O. Willoughby, "Excitation of neuronal function in rabbit caudal ventrolateral medulla elevates plasma vasopression," Neurosci. Lett.,58, No. 2, 189–194 (1985).

    Google Scholar 

  30. W. W. Blessing, S. C. Hedger, T. H. Joh, and J. O. Willoughby, "Neurons in the area postrema are the only catecholamine-synthesizing cells in the medulla or pons with projections to the rostral ventrolateral medulla (C1 area) in the rabbit," Brain Res.,419, No. 1/2, 336–340 (1987).

    Google Scholar 

  31. W. W. Blessing and J. O. Willoughby, "Depressor neurons in rabbit caudal medulla do not transmit the baroreceptor-vasomotor reflex," Am. J. Physiol.,253, No. 4, H777-H786 (1987).

    Google Scholar 

  32. W. W. Blessing, J. R. Oliver, A. H. Hodson,et al., "Neuropeptide Y-like immunoreactive C1 neurons in the rostral ventrolateral medulla of the rabbit project to the sympathetic preganglionic neurons in the spinal cord," J. Auton. Nervn. Syst.,18, No. 2, 121–129 (1987).

    Google Scholar 

  33. W. W. Blessing, "Depressor neurons in rabbit caudal medulla act via GABA receptors in rostral medulla," Am. J. Physiol.,254, No. 4, Pt. 2, H686-H692 (1988).

    Google Scholar 

  34. D. L. Brown and P. G. Guyenet, "Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats," Circ. Res.,56, No. 3, 359–369 (1985).

    Google Scholar 

  35. P. Bousquet, J. Feldman, J. Velly, and R. Block, "Role of the ventral surface of the brain stem in the hypotensive action of clonidine," Eur. J. Pharmacol.,34, No. 1, 151–156 (1975).

    Google Scholar 

  36. Bousquet, J. Feldman, R. Block, and J. Schwarts, "The ventromedullary hypotensive effect of muscimol in the anaesthetised cat," Clin. Exp. Hypertension,3, No. 1, 195–205 (1981).

    Google Scholar 

  37. M. M. Caversson, J. Ciriello, and F. R. Calaresu, "Direct pathway from cardiovascular neurones in the ventrolateral medulla to the region of the intermediolateral nucleus of the upper thoracic cord. An anatomical and electrophysiological investigation in the cat," J. Auton. Nervn. Syst.,9, No. 2/3, 451–475 (1983).

    Google Scholar 

  38. M. M. Caversson and J. Ciriello, "Electrophysiological identification of neurons in the ventrolateral medulla projecting directly to the nucleus solitary tract," Can. J. Physiol. Pharmacol.,62, No. 4, A ii (1984).

  39. M. M. Caversson, J. Ciriello, and F. R. Calaresu, "Chemoreceptor and baroreceptor inputs to ventrolateral medullary neurons," Am. J. Physiol.,247, No. 5, R872-R879 (1984).

    Google Scholar 

  40. C. V. Chai, R. H. Lin, A. M. Lin,et al., "Pressor responses from electrical or glutamate stimulations of the dorsal or ventrolateral medulla," Am. J. Physiol.,255, No. 5, Pt. 2, R709-R717 (1988).

    Google Scholar 

  41. J. Chalmers, J. Minson, V. Kapoor, and M. Cain, "Hypertension after brainstem (A1) lesions in normal state and in rats with adrenalectomy, sympathectomy or diabetes insipidus," Hypertension,2, Suppl. 3, 37–39 (1984).

    Google Scholar 

  42. R. K. Chan, V. S. Chan, and T. M. Wong, "Cardiovascular responses to electrical stimulation of the ventrolateral medulla of the spontaneously hypertensive rat," Brain Res.,522, No. 1, 99–106 (1990).

    Google Scholar 

  43. K. Chida, C. Iadecola, and D. J. Reis, "Lesions of rostral ventrolateral medulla abolish some cardio- and cerebrovascular components of the cerebellar fastigial pressor and depressor responses," Brain Res.,508, No. 1, 93–104 (1990).

    Google Scholar 

  44. J. Ciriello and F. R. Calaresu, "Lateral reticular nucleus: a site of somatic and cardiovascular integration in the cat," Am. J. Physiol.,233, No. 1, 100–109 (1977).

    Google Scholar 

  45. J. Ciriello and M. M. Caversson, "Ventrolateral medullary neurons relay cardiovascular inputs to the paraventricular nucleus," Am. J. Physiol.,246, No. 6, R968-R978 (1984).

    Google Scholar 

  46. J. Ciriello, M. M. Caversson, and C. Polosa, "Function of the ventrolateral medulla in the control of the circulation," Brain Res. Rev.,11, No. 2, 359–391 (1986).

    Google Scholar 

  47. J. Ciriello, M. M. Caversson, and C. Polosa, "The central neural organisation of cardiovascular control," Progr. Brain Res.,81, 334 (1989).

    Google Scholar 

  48. K. L. Cochrane, R. A. Buchholtz, J. W. Hubbard, et al., "Hypotensive effects of lesions of the rostral ventrolateral medulla in rats are anaesthetic-dependent," J. Auton. Nervn. Syst.,22, No. 3, 181–188 (1988).

    Google Scholar 

  49. P. B. Corr, B. Pitt, B. H. Natelson, et al., "Task force 3: sudden cardiac death," Circulation,76, No. 1, Pt. 2, Suppl. 1, 208–214 (1987).

    Google Scholar 

  50. T. A. Day, A. Ro, and L. P. Renaud, "Depressor area within caudal ventrolateral medulla of the rat does not correspond to the A1 catecholamine cell group," Brain Res.,279, No. 2, 299–302 (1983).

    Google Scholar 

  51. Y. A. Day and J. R. Sibbald, "Al cell group mediates solitary nucleus excitation of supraoptic vasopressin cells," Am. J. Physiol.,257, No. 5, Pt. 2, R1020-R1026 (1989).

    Google Scholar 

  52. R. A. Dampney, A. K. Goodchild, I. G. Robertson, and W. Montgomery, "Role of ventrolateral medulla in vasomotor regulation: a correlative anatomical and physiological study," Brain Res.,249, No. 2, 223–235 (1982).

    Google Scholar 

  53. R. A. Dampney, J. Czachurski, K. Dembowski, and H. Seller, "Afferent and efferent connections of the rostral ventrolateral pressor region in the medulla oblongata of the cat," Pflugers Arch.,403, Suppl., R51 (1985).

  54. R. A. L. Dampney, A. K. Goodchild, and E. Tan, "Vasopressor neurons in the rostrolateral medulla of the rabbit," J. Auton. Nervn. Syst.,14, No. 3, 239–254 (1985).

    Google Scholar 

  55. R. A. Dampney, A. K. Goodchild, and R. M. McAllen, "Vasomotor control by subretrofacial neurones in the rostral ventrolateral modulla," Can. J. Physiol. Pharmacol.,65, No. 8, 1572–1579 (1987).

    Google Scholar 

  56. K. Dembrowsky, K. Lackner, J. Czachurski, and H. Seller, "Tonic catecholaminergic inhibition of the spinal somatosympathetic reflexes originating in the ventrolateral medulla oblongata," J. Auton. Nervn. Syst.,3, No. 2/4, 277–290 (1981).

    Google Scholar 

  57. K. Dembrowsky and H. Seller, "Synaptic inputs from the pressor area of the rostral ventrolateral medulla oblongata to sympathetic preganglionic neurons of the third thoracic segment in the cat," Pflugers Arch.,403, Suppl., R51 (1985).

  58. R. Dermitzel, "Acid-base homeostasis of the brain extracellular fluid and respiratory control system," in: Central Chemosensitivity, Morphological Studies, H. Loeschke (ed.), Stuttgart (1976), pp. 52–66.

  59. K. J. Dormer, R. J. Person, J. A. Andrezik, et al., "Ventrolateral medullary lesions and fastigial cardiovascular response in beagles," Am. J. Physiol.,256, No. 4, Pt. 2, H1200-H1208 (1989).

    Google Scholar 

  60. J. M. Elliot, V. Kapoor, M. Cain, et al., "The mechanism of hypertension and bradycardia following lesions of the caudal ventrolateral medulla in the rabbit: the role of sympathetic nerves, circulating adrenaline, vasopressin and renin," Clin. Exp. Hypertension,7, No. 8, 1059–1082 (1985).

    Google Scholar 

  61. W. Feldberg and P. G. Guertzenstein, "A vasodepressor effect of pentobarbitone sodium," J. Physiol.,224, No. 1, 83–103 (1972).

    Google Scholar 

  62. W. Feldberg and P. G. Guertzenstein, "Vasodepressor effects obtained by drugs acting on the ventral surface of the brain stem," J. Physiol.,258, No. 2, 337–355 (1976).

    Google Scholar 

  63. W. Feldberg, "Cardiovascular effects of drugs acting on the ventral surface of the brain stem," in: Central Interaction of Respiratory and Cardiovascular Control Systems, Berlin (1980), pp. 47–53.

  64. J. C. W. Finley, J. L. Maderdrut, and P. Petrusz, "The immunocytochemical localization of enkephalin in the central nervous system of the rat," J. Comp. Neurol.,198, No. 4, 541–565 (1981).

    Google Scholar 

  65. Ph. J. Gatti, W. P. Norman, T. A. M. Dasilva, and R. A. Gillis, "Cardiorespiratory effects produced by micro-injecting L-glutamic acid into medullary nuclei associated with the ventral surface of the feline medulla," Brain Res.,381, No. 2, 281–288 (1986).

    Google Scholar 

  66. P. J. Gatti and R. A. Gillis, "Interaction between pressor and depressor areas in cat ventrolateral medulla," Brain Res.,552, No. 1, 153–158 (1991).

    Google Scholar 

  67. A. J. Gelsema, S. K. Agarwal, and F. R. Calaresu, "Cardiovascular responses and changes in neuronal activity in the rostral ventrolateral medulla elicited by electrical stimulation of the amygdala of the rat," J. Auton. Nervn. Syst.,27, No. 2, 91–100 (1989).

    Google Scholar 

  68. R. A. Gillis, D. P. Walton, J. A. Quest, et al., "Cardiorespiratory effects produced by activation of cholinergic muscarinic receptors on the ventral surface of the medulla," J. Pharmacol. Exp. Therap.,247, No. 2, 765–773 (1988).

    Google Scholar 

  69. A. R. Granata, D. A. Ruggiero, D. H. Park, et al., "Lesions of epinephrine neurons in the rostral ventrolateral medulla abolish the vasodepressor components of baroreflex and cardiopulmonary reflex," Hypertension,5, No. 6, Pt. 3, 80–84 (1983).

    Google Scholar 

  70. A. R. Granata, D. A. Ruggiero, Y. Numao, et al., "The area of rostral ventrolateral medulla containing C1 adrenaline neurons mediates the hypertension produced by lesions of Al noradrenergic neurons," Hypertension,6, No. 5, 786–790 (1984).

    Google Scholar 

  71. A. R. Granata, D. A. Ruggiero, D. H. Park, and D. J. Reis, "Brain stem area with C1 epinephrine neurons mediates baroreflex vasodepressor responses," Am. J. Physiol.,248, No. 4, H547-H567 (1985).

    Google Scholar 

  72. A. R. Granata, M. Kumada, and D. J. Reis, "Sympathoinhibition by A1 noradrenergic neurons is mediated by neurons in the C1 area of the rostral medulla," J. Auton. Nervn. Syst.,14, No. 4, 387–395 (1985).

    Google Scholar 

  73. T. J. Gordon and L. A. McCann, "Cardiopulmonary reflexes are mediated by N-methyl-D-aspartic acid (NMDA) receptors in caudal ventrolateral medulla (CVM)," FASEB J.,3, No. 3, 529 (1989).

    Google Scholar 

  74. P. G. Guertzenstein and A. Silver, "Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions," J. Physiol.,242, No. 2, 489–593 (1974).

    Google Scholar 

  75. P. G. Guyenet and B. B. Young, "Projections of nucleus paragigantocellularis to locus coeruleus and other structures in rat," Brain Res.,406, No. 1/2, 171–184 (1987).

    Google Scholar 

  76. P. G. Guyenet and D. L. Brown, "Nucleus paragigantocellularis lateralis and lumber sympathetic discharge in the rat," Am. J. Physiol.,250, No. 6, 1081–1094 (1986).

    Google Scholar 

  77. J. R. Haselton and P. G. Guyenet, "Ascending collaterals of medullary barosensitive neurons and C1 cells in rats," Am. J. Physiol.,258, No. 4, Pt. 2, R1051-R1063 (1990).

    Google Scholar 

  78. M. B. Hancock and A. P. Nicholas, "Oxytocin-immunoreactive projections onto medullary adrenaline neurons," Brain Res. Bull.,18, No. 2, 213–219 (1987).

    Google Scholar 

  79. C. J. Helke, J. J. Nei, V. J. Massari, and A. D. Loewy, "Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat," Brain Res. Bull.,243, No. 1, 147–152 (1982).

    Google Scholar 

  80. C. J. Helke, C. W. Schults, T. N. Chase, and T. L. O'Donohue, "Autoradiographic localisation of substance P receptors in rat medulla: effect of vagotomy and nodose ganglionectomy," Neuroscience,12, No. 1, 215–223 (1984).

    Google Scholar 

  81. C. J. Helke, C. G. Charlton, and J. R. Keeler, "Bulbospinal substance P and sympathetic regulation of the cardiovascular system: a review," Peptides,6, Suppl. 2, 69–74 (1985).

    Google Scholar 

  82. S. M. Hilton, "The defence-arousal system and its relevance for circulatory and respiratory control," J. Exp. Biol.,100, No. 1, 159–174 (1982).

    Google Scholar 

  83. S. M. Hilton, J. M. Marshall, and R. J. Timms, "Ventral medullary relay neurons in the pathway from the defence areas of the cat and their effect on blood pressure," J. Physiol.,345, 149–166 (1983).

    Google Scholar 

  84. T. Hokfelt, K. Fuxe, M. Goldstein, and O. Johansson, "Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain," Brain Res.,66, No. 2, 235–251 (1974).

    Google Scholar 

  85. T. Hokfelt, R. Elde, O. Johansson, et al., "The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system," Neurosci. Lett.,5, No. 1, 25–31 (1977).

    Google Scholar 

  86. T. Imazumi, A. R. Granata, E. E. Benarroch, et al., "Contribution of arginine vasopressin and the sympathetic nervous system to fulminating hypertension after destruction of neurons of caudal ventrolateral medulla in the rat," Hypertension,3, No. 5, 491–501 (1985).

    Google Scholar 

  87. H. Kannan, M. Kasai, T. Osaka, and H. Yamashita, "Neurons in the paraventricular nucleus projecting in the median eminence: a study of their afferent connections from peripheral baroreceptors and from the A1-catecholaminergic area in the ventrolateral medulla," Brain Res.,409, No. 2, 358–361 (1987).

    Google Scholar 

  88. J. R. Keeler, C. W. Shults, T. N. Chase, and C. J. Helke, "The ventral surface of the medulla in the rat: pharmacological and autoradiographic localisation of GABA-induced cardiovascular effects," Brain Res.,297, No. 2, 217–224 (1984).

    Google Scholar 

  89. M. Kihara and T. Kubo, "Cardiovascular effects of GABA system activating drugs injected into the caudal ventrolateral medulla of the rat," Arch. Int. Pharmacodyn.,295, No. 1, 67–79 (1988).

    Google Scholar 

  90. J. F. Kille and M. E. Schlafke, "Histological investigations in the chemosensitive areas on the ventral surface of the medulla oblongata," Pflugers Arch.,339, Suppl., P76 (1974).

  91. J. F. Kille and M. E. Schlafke, "Do ventral medullary neurons control cardiorespiratory system in man?" Pflugers Arch.,406, Suppl., R25 (1986).

  92. T. Kubo, H. Amano, and Y. Misu, "Caudal ventrolateral medulla. A region responsible for mediation of vasopressin-induced pressor responses," Arch. Pharmacol.,328, No. 4, 368–372 (1985).

    Google Scholar 

  93. T. Kubo, "Involvement of the ventrolateral medulla in the mediation of the pressor responses of the rat to afferent vagal stimulation," Can. J. Physiol.,63, No. 12, 1612–1614 (1985).

    Google Scholar 

  94. T. Kubo and M. Kihara, "N-methyl-D-aspartate receptors mediate tonic vasodepressor control in the caudal ventrolateral medulla of the rat," Brain Res.,451, No. 1/2, 366–370 (1988).

    Google Scholar 

  95. Yu-W. Li and W. W. Blessing, "Localisation of vasodepressor neurons in the caudal ventrolateral medulla in the rabbit," Brain Res.,517, No. 1/2, 57–63 (1990).

    Google Scholar 

  96. B. Lown, "Sudden cardiac death: behavioral perspective," Circulation,76, No. 1, Suppl. 1, Pt. 2, 186–196 (1987).

    Google Scholar 

  97. A. Ljungdahl, T. Hokfelt, G. Nilson, and M. Goldstein, "Distribution of substance P-like immunoreactivity in the central nervous system of the rat. II: light microscopic localisation in relation to catecholamine-containing neurons," Neuroscience,3, No. 10, 945–976 (1978).

    Google Scholar 

  98. H. H. Loeschke, "Central chemosensitivity and the reaction theory," J. Physiol.,332, No. 1, 17–24 (1982).

    Google Scholar 

  99. A. D. Loewy and S. McKellar, "Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat," Brain Res.,211, No. 1, 146–152 (1981).

    Google Scholar 

  100. A. D. Loewy, J. H. Wallach, and S. McKellar, "Efferent connections of the ventral medulla oblongata in the rat," Brain Res. Rev.,3, No. 1, 63–80 (1981).

    Google Scholar 

  101. A. D. Loewy and W. B. Sawyer, "Substance P antagonist inhibits vasomotor responses elicited from ventral medulla in rat," Brain Res.,245, No. 2, 379–383 (1982).

    Google Scholar 

  102. T. A. Lovick and S. M. Hilton, "Vasodilator and vasoconstrictor neurons of the ventrolateral medulla in the cat," Brain Res.,331, No. 2, 353–357 (1985).

    Google Scholar 

  103. T. A. Lovick, "Differential control of cardiac and vasomotor activity by neurons in nucleus paragiganto-cellularis lateralis in the cat," J. Physiol.,389, 23–25 (1987).

    Google Scholar 

  104. T. A. Lovick, "Hypotensive action of 5-HT in the ventrolateral medulla of anaesthetized rats," J. Physiol.,412, 14P (1989).

  105. L. Marson and A. D. Loewy, "Topographic organization of substance P and monoamine cells in the ventral medulla of the cat," J. Auton. Nervn. Syst.,14, No. 3, 271–285 (1985).

    Google Scholar 

  106. R. M. McAllen, J. J. Neil, and A. D. Loewy, "Effects of kainic acid applied to the ventral surface of the medulla oblongata on vasomotor tone, the baroreceptor reflex and hypothalamic autonomic responses," Brain Res.,238, No. 1, 65–78 (1982).

    Google Scholar 

  107. R. M. McAllen, "Mediation of the fastigial pressor responses and a somatosympathetic reflex by ventral medullary neurons in the cat," J. Physiol.,368, 413–433 (1985).

    Google Scholar 

  108. R. M. McAllen, "Identification and properties of subretrofacial bulbospinal neurons: a descending cardiovascular pathway in the cat," J. Auton. Nervn. Syst.,17, No. 1, 151–164 (1986).

    Google Scholar 

  109. R. M. McAllen and W. W. Blessing, "Neurons (presumably Al cells) projecting from the caudal ventrolateral medulla to the region of supraoptic nucleus respond to baroreceptor inputs in the rabbit," Neurosci. Lett.,73, No. 3, 247–252 (1987).

    Google Scholar 

  110. E. M. McLachlan, C. R. Anderson, and A. D. Sinclair, "Are there bulbospinal catecholaminergic neurons in the guinea pig equivalent to the C1 cell group in the rat and rabbit?" Brain Res.,481, No. 2, 274–285 (1989).

    Google Scholar 

  111. M. P. Meeley, D. A. Ruggiero, T. Ishitsuka, and D. J. Reis, "Intrinsic γ-aminobutyric acid neurons in the nucleus of the solitary tract and the rostral ventrolateral medulla of the rat: immunocytochemical and biochemical study," Neurosci. Lett.,58, No. 1, 83–89 (1985).

    Google Scholar 

  112. D. E. Millhorn, T. Hokfelt, K. Seroogy, et al., "Immunohistochemical evidence for colcalisation of ventral medulla oblongata gamma-aminobutyric acid and serotonin in neurons projecting to the spinal cord," Brain Res.,410, No. 1, 179–185 (1987).

    Google Scholar 

  113. D. E. Millhorn, K. Seroogy, T. Hokfelt, et al., "Neurons of the ventral medulla oblongata that contain both somatostatin and enkephalin immunoreactivities project to nucleus tractus solitarii and spinal cord," Brain Res.,424, No. 1, 99–108 (1987).

    Google Scholar 

  114. T. A. Milner, V. M. Pickel, D. H. Park, et al., "Phenylethanolamine N-methyltransferase-containing neurons in the rostral ventrolateral medulla of the rat. I. Normal ultrastructure," Brain Res.,411, No. 1, 28–45 (1987).

    Google Scholar 

  115. T. A. Milner, V. M. Pickel, J. Chan, et al., "Phenylethanolamine N-methyltransferase-containing neurons in the rostral ventrolateral medulla. II. Synpatic relationships with GABA-ergic terminals," Brain Res.,411, No. 1, 46–57 (1987).

    Google Scholar 

  116. T. A. Milner, S. F. Morrison, C. Abate, and D. J. Reis, "Phenylethanolamine N-methyltransferase-containing terminals synapse directly on sympathetic preganglionic neurons in the rat," Brain Res.,448, No. 1, 205–222 (1988).

    Google Scholar 

  117. T. A. Milner, V. M. Pickel, and D. J. Reis, "Ultrastructural basis for interactions between central opiods and catecholamines. I. Rostral ventrolateral medulla," J. Neurosci.,9, No. 6, 2114–2130 (1989).

    Google Scholar 

  118. T. A. Milner, V. M. Pickel, C. Abate, et al., "Ultrastructural characterization of substance P-like immunoreactive neurons in the rat rostral ventrolateral medulla in relation to neurons containing catecholamine synthesizing enzymes," J. Comp. Neurol.,270, No. 4, 427–445 (1988).

    Google Scholar 

  119. T. A. Milner, V. M. Pickel, R. Giuliano, and D. J. Reis, "Ultrastructural localization of choline acetyltransferase in the rat rostral ventrolateral medulla: evidence for major synaptic relations with non-catecholaminergic neurons," Brain Res.,500, No. 1/2, 67–89 (1989).

    Google Scholar 

  120. J. Minson, J. Chalmers, V. Kapoor, et al., "Relative importance of sympathetic nerves and of circulating adrenaline and vasopressin in mediating hypertension after lesions of the caudal ventrolateral medulla in the rat," Hypertension,4, No. 3, 273–281 (1986).

    Google Scholar 

  121. R. A. Mitchell, H. H. Loeschke, W. H. Massion, and J. W. Severinghaus, "Respiratory responses mediated through superficial chemosensitive areas on the medulla," J. Appl. Physiol.,18, No. 3, 523–533 (1963).

    Google Scholar 

  122. S. Morrison and D. J. Reis, "Reticulospinal vasomotor neurons in the RVL mediate the somatosympathetic reflex," Am. J. Physiol.,256, No. 5, Pt. 2, R1084-R1097 (1989).

    Google Scholar 

  123. J. Murygaian, K. Sundaram, and H. Sapru, "Cholinergic mechanisms in the ventrolateral medullary depressor area," Brain Res.,501, No. 2, 355–363 (1989).

    Google Scholar 

  124. P. Pilowsky, M. West, and J. Chalmers, "Renal sympathetic nerve responses to stimulation, inhibition and destruction of the ventrolateral medulla in the rabbit," Neurosci. Lett.,60, No. 1, 51–55 (1985).

    Google Scholar 

  125. P. M. Pilowsky, M. J. Morris, J. B. Minson, et al., "Inhibition of vasedepressor neurons in the caudal ventrolateral medulla of the rabbit increases both arterial pressure and release of neuropeptide Y-like immunoreactivity from the spinal cord," Brain Res.,420, No. 2, 380–384 (1987).

    Google Scholar 

  126. C. Polosa, F. Lioy, and B. D. Honna, "The role of the ventral medulla in the control of sympathetic activity by systemic arterial CO2," in: Central Neurone Environment, M. E. Schlafke, et al., editors, Springer-Verlag, Berlin; Heidelberg (1983), pp. 214–220.

    Google Scholar 

  127. S. Punnen, R. Willette, A. J. Krieger, and H. N. Sapru, "Cardiovascular response to injections of enkephalin in the pressor area of the ventrolateral medulla," Neuropharmacology,23, No. 8, 939–946 (1984).

    Google Scholar 

  128. S. Punnen and A. N. Sapru, "Blockade of cholinergic responses in opiates in the A1 area of the ventrolateral medulla," Brain Res.,336, No. 1, 180–186 (1985).

    Google Scholar 

  129. S. Punnen, R. Urbanski, A. J. Krieger, and H. N. Sapru, "Ventrolateral medullary pressure area: site of hypertensive action of clonidine," Brain Res.,422, No. 2, 336–346 (1987).

    Google Scholar 

  130. D. J. Reis, C. A. Ross, D. A. Ruggiero, et al., "Role of adrenaline neurons of the ventrolateral medulla (the C1 group) in the tonic and phasic control of arterial pressure," Clin. Exp. Hypertension,6, No. 1/2, 221–241 (1984).

    Google Scholar 

  131. D. J. Reis, "C1 area of brainstem regulates arterial pressure; clonidine may bind to two types of receptors there," Heart Circulation,3, Suppl. 2, 5–6 (1988).

    Google Scholar 

  132. D. J. Reis, S. Morrison, and D. A. Ruggiero, "The C1 area of the brainstem in tonic and reflex control of blood pressure. State of the art lecture," Hypertension,11, No. 2, Pt. 2, Suppl. 8–13 (1988).

  133. D. J. Reis, C. Ross, A. R. Granata, and D. A. Ruggiero, "Role of C1 area of rostroventrolateral medulla in cardiovascular control," in: Brain Peptides and Catecholamines in Cardiovascular Regulation, J. P. Buckley and C. M. Ferrario (eds.), Raven Press, New York (1987), pp. 1–14.

    Google Scholar 

  134. J. P. Rosenfeld, and K. H. Huang, L. Y. Xia, "Effects of single and simultaneous combined microinjections of Met-enkephalin into rat midbrain and medulla on activity of differentially responsive ventral medullary neurons," Brain Res.,508, No. 2, 199–209 (1990).

    Google Scholar 

  135. C. A. Ross, D. A. Ruggiero, T. H. Joh, et al., "Adrenaline synthesizing neurons in the rostral ventrolateral medulla: a possible role in tonic vasomotor control," Brain Res.,273, No. 2, 356–361 (1983).

    Google Scholar 

  136. C. A. Ross, D. A. Ruggiero, T. H. Joh, et al., "Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons," J. Comp. Neurol.,228, No. 1, 168–184 (1984).

    Google Scholar 

  137. C. A. Ross, D. A. Ruggiero, D. H. Park, et al., "Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate and plasma catecholamines and vasopressin," J. Neurosci.,4, No. 2, 747–794 (1984).

    Google Scholar 

  138. Ch. A. Ross, D. A. Ruggiero, and D. J. Reis, "Projections from the nucleus tractus solitary to the rostral ventrolateral medulla," J. Comp. Neurol.,242, No. 4, 511–534 (1985).

    Google Scholar 

  139. D. A. Ruggiero, C. A. Ross, M. Anwar, et al., "Distribution of neurons containing phenylethanolamine-N-methyltransferase in medulla and hypothalamus of rat," J. Comp. Neurol.,239, No. 1, 127–154 (1985).

    Google Scholar 

  140. D. A. Ruggiero, M. P. Meeley, M. Anwar, and D. J. Reis, "Newly identified GABA-ergic neurons in regions of the ventrolateral medulla that regulate blood pressure," Brain Res.,339, No. 1, 171–177 (1985).

    Google Scholar 

  141. D. A. Ruggiero and D. J. Reis, "Rostral ventrolateral medulla: site of autonomic integration," Acta Physiol. Scand.,136, Suppl. 584, 37 (1989).

    Google Scholar 

  142. T. Schaefer, M. E. Schlafke, and D. Schaefer, "Instability of chemoreflexes causally involved in sudden infant death syndrome?" Pflugers Arch.,408, Suppl. 1, R64 (1987).

  143. M. Schlafke and H. H. Loeschke, "Localisation eines Regulation von Atmug und Kreislauf beteiligten Gebients an der Ventralen Oberlasche der Medulla oblongata durch Kalteblockade," Pflugers Arch.,297, No. 1, 201–220 (1967).

    Google Scholar 

  144. W. R. See and M. E. Schlafke, "The influence of sinus nerve stimulation on neuronal activity by ventral medullary neurons," Neurosci. Lett.,11, Suppl. 1, 19–21 (1978).

    Google Scholar 

  145. H. Seller, J. Czachurski, S. Konig, and K. Dembrowsky, "Chemosensitivity of sympathoexcitatory neurons in the rostral ventrolateral medulla," Acta Physiol. Scand.,136, Suppl. 584, 38 (1989).

    Google Scholar 

  146. J. K. Smith and K. W. Barron, "Cardiovascular effects of L-glutamate and tetrodotoxin microinjected into the rostral and caudal ventrolateral medulla in normotensive and spontaneously hypertensive rats," Brain Res.,506, No. 1, 1–8 (1990).

    Google Scholar 

  147. J. K. Smith and K. W. Barron, "GABA-ergic responses in ventrolateral medulla in spontaneously hypertensive rats," Am. J. Physiol.,258, No. 2, 450–456 (1990).

    Google Scholar 

  148. P. Somogyi, J. B. Minson, D. Morilak, et al., "Evidence for an excitatory amino acid pathway in the brainstem and for its involvement in cardiovascular control," Brain Res.,496, No. 1/2, 401–407 (1989).

    Google Scholar 

  149. R. L. Stornetta, S. F. Morrison, D. A. Ruggiero, and D. J. Reis, "Neurons of rostral ventrolateral medulla mediate somatic pressor reflex," Am. J. Physiol.,256, No. 2, Pt. 2, R448-R469 (1989).

    Google Scholar 

  150. M. K. Sun, B. S. Young, J. T. Hokfelt, and P. G. Guyenet, "Rostral ventrolateral medullary neurons with intrinsic pacemaker properties area not catecholaminergic," Brain Res.,451, No. 1/2, 345–349 (1988).

    Google Scholar 

  151. M. K. Sun, J. T. Hokfelt, and P. G. Guyenet, "Sympathoexcitatory neurons of rostral ventrolateral medulla exhibit pacemaker properties in presence of a glutamate-receptor antagonist," Brain Res.,438, No. 1, 23–40 (1988).

    Google Scholar 

  152. M. K. Sun and P. G. Guyenet, "Effects of vasopressin and other neuropeptides on rostral medullary sympathoexcitatory neurons ‘in vitro’," Brain Res.,492, No. 1/2, 261–270 (1989).

    Google Scholar 

  153. M. K. Sun and P. G. Guyenet, "Excitation of rostral medullary pacemaker neurons with putative sympathoexcitatory function by cyclic AMP and beta-adrenoceptor agonist ‘in vitro’," Brain Res.,511, No. 1, 30–40 (1990).

    Google Scholar 

  154. K. Sundaram and H. Sapru, "Cholinergic nerve terminals in the ventrolateral medullary pressor area: pharmacological evidence," J. Auton. Nervn. Syst.,22, No. 3, 221–228 (1988).

    Google Scholar 

  155. I. Tanaka, H. Kuba, and H. Saito, "The Al noradrenergic region enhances the responsibility of hypothalamic paraventricular neurohypophyseal neurons to inputs from the subfornical organ in the rat," Exp. Brain Res.,68, No. 3, 586–592 (1987).

    Google Scholar 

  156. N. Terui, Y. Sacki, and M. Kumada, "Confluence of barosensory and nonbarosensory inputs at neurons in the ventrolateral medulla in rabbits," Can. J. Physiol. Pharmacol.,65, No. 8, 1584–1590 (1987).

    Google Scholar 

  157. C. O. Trouth, H. H. Loeschke, and J. Berndt, "Histological structures in chemosensitive regions on the ventral surface of the cat's medulla oblongata," Pflugers Arch.,339, No. 1, 171–183 (1973).

    Google Scholar 

  158. D. C. Tucker, C. B. Saper, D. A. Ruggiero, and D. J. Reis, "Organization of central adrenergic pathways. I. Relationships of ventrolateral medullary projections to the hypothalamus and spinal cord," J. Comp. Neurol.,259, No. 3, 591–603 (1987).

    Google Scholar 

  159. R. W. Urbanski, J. Murugaian, A. J. Krieger, and H. N. Sapru, "Cardiovascular effects of substance P receptor stimulation in the ventrolateral medullary pressor and depressor areas," Brain Res.,491, No. 2, 383–389 (1989).

    Google Scholar 

  160. Q. Wang and P. Li, "Stimulation of ventrolateral medulla inhibits the baroreceptor," Brain Res.,473, No. 2, 227–235 (1988).

    Google Scholar 

  161. G. Wennergren and B. Oberg, "Cardiovascular effects elicited from the ventral surface of the medulla oblongata in the cat," Pflugers Arch.,387, No. 1, 189–195 (1980).

    Google Scholar 

  162. M. J. West, W. W. Blessing, and J. P. Chalmers, "Arterial baroreceptor reflex function in the conscious rabbit after brainstem lesions coinciding with the Al group of catecholamine neurons," Brain Res.,49, No. 3, 959–970 (1981).

    Google Scholar 

  163. I. M. Willenberger, R. Dermitzel, A. G. Leibstein, and M. Effenberger, "Mapping of cholinoceptive (nicotinoceptive) neurons in the lower brainstem with special reference to the ventral surface of the medulla," J. Auton. Nervn. Syst.,14, No. 3, 287–298 (1985).

    Google Scholar 

  164. R. N. Willette, A. J. Krieger, P. P. Barcas, and H. P. Sapru, "Medullary γ-aminobutyric acid (GABA) receptors and the regulation of blood pressure in the rat," J. Pharmacol. Exp. Ther.,226, No. 3, 893–899 (1983).

    Google Scholar 

  165. R. N. Willette, P. P. Barcas, A. J. Krieger, and H. N. Sapru, "Vasopressor and depressor areas in the rat medulla. Identification by microinjection of L-glutamate," Neuropharmacology,22, No. 10, 1071–1079 (1983).

    Google Scholar 

  166. P. N. Willette, S. Punnen, A. J. Krieger, and H. N. Sapru, "Cardiovascular control by cholinergic mechanism in the rostral ventrolateral medulla," J. Pharmacol. Exp. Ther.,231, No. 2, 457–463 (1984).

    Google Scholar 

  167. R. N. Willette, P. A. Gatti, and H. N. Sapru, "GABA-ergic mechanisms in the ventrolateral medulla after vasopressor responses from the anterior hypothalamus," J. Cardiovasc. Pharmacol.,6, No. 2, 476–482 (1984).

    Google Scholar 

  168. R. N. Willette, S. Punnen, A. J. Krieger, and H. N. Sapru, "Interdependence of rostral and caudal ventrolateral medullary areas in the control of blood pressure," Brain Res.,321, No. 1, 169–174 (1984).

    Google Scholar 

  169. R. N. Willette, S. Punen-Grandy, A. J. Krieger, and H. N. Sapru, "Differential regulation of regional vascular resistance by the rostral and caudal ventrolateral medulla in the rat," J. Auton. Nerv. Syst.,18, No. 2, 143–151 (1987).

    Google Scholar 

  170. R. G. Williams and G. J. Dockray, "Distribution of enkephalin related peptides in rat brain: immunohistochemical studies using antisera to met-enkephalin and met-enkephalin Arg6 Phe7," Neuroscience,9, No. 3, 563–586 (1983).

    Google Scholar 

  171. K. A. Yamada, R. M. McAllen, and A. D. Loewy, "GABA antagonists applied to the ventral surface of the medulla oblongata block the baroreceptor reflex," Brain Res.,297, No. 1, 175–180 (1984).

    Google Scholar 

  172. Y. Yosui, D. F. Cechetto, and C. B. Saper, "Evidence for a cholinergic projection from the pedunculopontine tegmental nucleus to the rostral ventrolateral medulla in the rat," Brain Res.,517, No. 1/2, 19–24 (1990).

    Google Scholar 

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A. A. Bogomolets Institute of Physiology, Ukrainian Academy of Sciences, Kiev. Translated from Neirofiziologiya, Vol. 24, No. 6, pp. 717–735, November–December, 1992.

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Shapoval, L.N. The role of structures of the ventrolateral medulla in cardiovascular regulation. Neurophysiology 24, 483–499 (1992). https://doi.org/10.1007/BF01052968

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