Abstract
Connections of the retrosplenial cortex with the hippocampus in rats were investigated by the method of retrograde axonal transport of horseradish peroxidase (HRP). If a crystal of HRP was introduced into the dorsocaudal part of the retrosplenial cortex, HRP-labeled cells were found in the rostral pole of hippocampal area CA3 and in the presubiculum. After iontophoretic injection of HRP into the rostral pole of the hippocampus, HRP-labeled cells were found in layers V and VI of the retrosplenial cortex and in the presubiculum. The results are evidence of reciprocity of direct connections between the rostral pole of the hippocampus and the retrosplenial cortex, and also of the existence of direct efferents of the dorsal subiculum to the rostral pole of the hippocampus.
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Literature cited
T. W. Berger, G. W. Swanson, T. A. Milner, et al., "Reciprocal anatomical connections between hippocampus and subiculum in the rabbit: evidence for subicular innervation of regio superior," Brain Res.,183, No. 2, 265 (1980).
V. B. Domesick, "Thalamic relationships of the medial cortex in the rat," Brain, Behav. Evol.,6, 457 (1972).
E. Fifkova and J. Marsala, Stereotaxic Podkorovych Struktur Mozku Krysy, Kralika a Kocky, Prague (1960).
W. J. S. Krieg, "Connections of the cerebral cortex. 1. The albino rat. A. Topography of the cortical areas," J. Comp. Neurol.,84, No. 2, 221 (1946).
R. C. Meibach and A. Siegel, "Subicular projections to the posterior cingulate cortex in rats," Exp. Neurol.,57, No. 1, 264 (1977).
M. M. Mesulam, "The blue reaction product in horseradish peroxidase neurohistochemistry incubation parameters and visibility," J. Histochem. Cytochem.,24, No. 12, 1273 (1976).
G. Raisman, W. M. Cowan, and T. P. S. Powell, "The extrinsic afferent commissural and association fibres of the hippocampus," Brain.88, No. 5, 963 (1965).
S. E. Rose and C. L. Woolsey, "Structure and relations of limbic cortex and anterior thalamic nuclei in rabbit and cat," J. Comp. Neurol.,89, No. 2, 279 (1948).
D. L. Rosene and C. W. Van Hoesen, "Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey," Science,198, 69 (1977).
W. K. Schwerdtfeger, "Direct efferent and afferent connections of the hippocampus with the neocortex in the marmoset monkey," Amer. J. Anat.,156, No. 1, 77 (1979).
K. E. Sorensen, "Ipsilateral projection from the subiculum to the retrosplenial cortex in the guinea pig," J. Comp. Neurol.,193, No. 43, 893 (1980).
L. W. Swanson and W. M. Cowan, "An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat," J. Comp. Neurol.,172, No. 1, 49 (1977).
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I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 17, No. 1, pp. 102–107, January–February, 1985.
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Pakhomova, A.S., Akopyan, É.V. Direct connections of the hippocampus with the retrosplenial cortex in rats. Neurophysiology 17, 85–89 (1985). https://doi.org/10.1007/BF01052797
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DOI: https://doi.org/10.1007/BF01052797