Summary
In comparison to whole brain radiotherapy, local field radiotherapy in a consecutive series of 100 patients with malignant astrocytoma resulted in remarkably less toxicity. Survivorship is not different; the advantage is limited to the 7% long term survivors (defined as living 100% or more beyond median) since toxicity from brain radiation does not occur until a year or more after treatment.
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References
Walker MD, Alexander E Jr, Hunt WEet al.: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas: a cooperative trial. J Neurosurg 49: 333–343, 1978
Shapiro WR: Therapy of adult malignant brain tumor: what have the clinical trials taught us? Sem Oncol 13: 38–45, 1986
Sheline GE: Irradiation injury of the human brain: a review of clinical experience. In: Gilbert HA, Kagan ER (eds) Radiation damage to the nervous system. New York: Raven Press, pp 39–58, 1980
Groothuis DR, Vick NA: Radionecrosis of the central nervous system: the perspective of the clinical neurologist and neuropathologist. In: Gilbert HA, Kagan AR (eds) Radiation damage to the nervous system. New York: Raven Press, pp 93–106, 1980
Al-Mefty O, Kersh JE, Rough Aet al.: The long-term side effects of radiation therapy for benign brain tumors in adults. J Neurosurg 73: 502–512, 1990
Hohwieler ML, Lo TCM, Silverman MLet al.: Brain necrosis after radiotherapy for primary intracerebral tumor. Neurosurgery 18: 67–73, 1986
Maire JPL, Coudin B, Guerin Jet al: Neuropsychologic impairment in adults with brain tumors. Am J Clin Oncol 10: 156–162, 1987
Imperato JP, Paleologos NA, Vick NA: Effects of treatment on long-term survivors with malignant astrocytomas. Ann Neurol 28: 818–822, 1990
Archibald YM, Lunn D, Ruttan LAet al: Cognitive function in long-term survivors of high-grade glioma. J Neurosurg 80: 247–253, 1994
Hochberg FH, Pruitt A: Assumptions in the radiotherapy of glioblastoma. Neurology 30: 907–911, 1980
Wallner KE, Galicich JH, Krol Get al: Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma. Int J Radiat Oncol Biol Phys 16: 1405–1409, 1989
Shapiro WR, Green SB, Burger PCet al: Randomized trial of three chemotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. J Neurosurg 71: 1–9, 1989
Loeffler JS: Radiotherapy in managing malignant gliomas: current role and further directions. Adv Oncol 8: 14–20, 1992
Laperriere NJ, Bernstein M: Radiotherapy for brain tumors. CA Cancer J Clin 44: 96–108, 1994
Rutherford E: ‘If your experiment needs statistics, you ought to have done a better experiment.’ Quoted in: Bailey NTJ. The mathematical approach to biology and medicine. London: Wiley, 1967: 23
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Vick, N.A., Paleologos, N.A. External beam radiotherapy: Hard facts and painful realities. J Neuro-Oncol 24, 93–95 (1995). https://doi.org/10.1007/BF01052665
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DOI: https://doi.org/10.1007/BF01052665