Abstract
Male Wistar rats aged between 8 and 12 months were injected with 7–8 µl of aqueous L-leucine-14C (specific activity: 12543 megaBq/mM) in the region of the ventral horn at the level of segments L5,6 of the spinal cord. Radioactivity was investigated in 3 mm segments of the ventral roots concerned within 1 h in all series of experiments. Estradiol dipropionate, testosterone propionate, insulin, and small doses of thyroxine were found to accelerate axonal transport of labeled material, while hydrocortisone, large doses of thyroxine, as well as castration and thyroidectomy delayed this process. It was thus concluded that axonal transport is under clear-cut hormonal control.
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Institute of Gerontology, Academy of Medical Sciences of the USSR, Kiev. Translated from Neirofiziologiya, Vol. 22, No. 4, pp. 459–464, July–August, 1990.
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Frol'kis, V.V., Tanin, S.A. & Martsinko, V.I. Effects of hormones on axonal transport rate at the ventral root of the rat spinal cord. Neurophysiology 22, 336–341 (1990). https://doi.org/10.1007/BF01052472
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DOI: https://doi.org/10.1007/BF01052472