Abstract
Activity was recorded from neurons belonging to the representation of the forelimb in the motor cortex (sulcus cruciatus, L 7–9 mm) using multiple multi-channel/barrel electrodes during acute experiments on cats. Cross-correlation analysis of impulse trains was adopted to investigate dynamics of interneuronal connections during passive flexion and electrical stimulation of the limb contralateral to the recording site. It was found that neither passive bending nor electrical stimulation of the limb leads to a significant increase in the total number of direct relationships between cortical neurons. At the same time, passive flexion does produce a considerable decrease in the number of instances of both inputs operating in neighboring neurons (50–100 µm apart) and an increase in cells located further (between 100 and 400 µm) apart. Some increase in the number of direct inhibitory interactions between neighboring neurons was observed during electrical stimulation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
A. V. Bogdanov, A. G. Galashina, and V. N. Mats, "Functional connections between remote cortical neurons during and after setting up of time-linked feeding reflex," Zh. Vyssh. Nervn. Deyat.,38, No. 1, 164–166 (1988).
A. G. Galashina and A. V. Bogdanov, "Changes in functional connections between neighboring and distant cortical neurons in cats during the setting up of electrical defense reflex," Zh. Vyssh. Nervn. Deyat.,34, No. 3, 487–494 (1984).
A. G. Galashina and A. V. Bogdanov, "Plastic changes in network characteristics of neurons during habituation in cats," Zh. Vyssh. Nervn. Deyat.,35, No. 3, 442–448 (1984).
U. G. Gasanov, Systemic Activity in Cortical Neurons during Habituation [in Russian], Nauka, Moscow (1981).
B. Ya. Pyatigorskii, V. S. Zlenskaya, and G. M. Gruzdev, "Spike activity in pairs of caudate neurons in cats," Neirofiziologiya,10, No. 5, 486–493 (1978).
H. J. Aertsen and G. I. Gerstein, "Evolution of neuronal connectivity: sensitivity of cross-correlation," Brain Res.,340, No. 2, 341–354 (1985).
J. H. J. Allum, M. C. Hepp-Reymond, and K. Gusin, "Cross-correlation analysis of interneuronal connectivity in the motor cortex of monkey," Brain Res.,231, No. 2, 325–334 (1982).
J. W. Dickson and G. L. Gerstein, "Interactions between neurons in auditory cortex of the cat," J. Neurophysiol.,37, No. 6, 1239–1261 (1974).
P. M. Gochin, J. A. Kaltenbah, and G. L. Gerstein, "Coordinated activity of neuron pairs in anesthetized rat dorsal cochlear nucleus," Brain Res.,497, No. 1, 1–11 (1989).
J. K. Kelly and L. P. Renaud, "Physiological identification of inhibitory interneurons in the feline pericruciate cortex," J. Neuropharmacol.,13, No. 6, 463–474 (1974).
M. Kimura, K. Tanaka, and K. Toyama, "Interneuronal connectivity between visual cortical neurons of the cat as studied by cross-correlation analysis of their impulse discharges," Brain Res.,118, No. 2, 97–107 (1976).
A. Michalski, G. L. Gerstein, I. Czarkowska, and R. Tarnecki, "Interaction between cat striate cortex neurons," Exp. Brain Res.,5, No. 1, 97–107 (1976).
A. Michalski, M. Kossut, I. Chmielowska, and K. Turlejski, "Cross-correlation analysis of intracolumnar neuronal connectivity in area 17 of binocularly deprived cats," Acta Neurobiol. Exp.,44, No. 1, 1–15 (1984).
D. A. Perkel, G. L. Gerstein, and G. P. Moor, "Neuronal spike trains and stochastic point process," Biophys. J.,1, No. 7, 391–398 (1967).
R. Tarnecki, "Functional connections between neurons of interpositus nucleus of the cerebellum and red nucleus," Behaviour, Brain Res.,28, No. 1/2, 117–125 (1988).
K. Toyama, M. Kimura, and K. Tanaka, "Cross-correlation analysis of interneuronal connectivity in cat visual cortex," J. Neurophysiol,46, No. 2, 191–201 (1981).
K. Toyama, M. Kimura, and K. Tanaka, "Organization of cat visual cortex as investigated by cross-correlation technique," J. Neurophysiol.,46, No. 2, 202–214 (1981).
H. F. Voight and E. D. Young, "Evidence of inhibitory interactions between neurons in dorsal cochlear nucleus," J. Neurophysiol.,44, No. 1, 76–96 (1980).
Additional information
Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Nentskii Institute of Experimental Biology, Warsaw, Poland. Center of Experimental and Clinical Medicine, Warsaw, Poland. Translated from Neirofiziologiya, Vol. 23, No. 1, pp. 73–80, January–February, 1991.
Rights and permissions
About this article
Cite this article
Bogdanov, A.V., Kaluzhnyi, O., Tarnetskii, R. et al. Dynamics of functional reciprocal connections between cerebral motor cortex neurons under stimulation in cats. Neurophysiology 23, 61–66 (1991). https://doi.org/10.1007/BF01052291
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01052291