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Modulatory effects of oxytocin on functional properties of three types of cholinoreceptors in molluskan neurons

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Abstract

It was found that applying 10−8 M oxytocin (OT) affects the functional properties of three types of cholinoreceptors under conditions of voltage clamping at the membrane of identified ganglia neurons inHelix pomatia. This neuropeptide depressed acetycholine-(ACh-)induced sodium-potassium-calcium current in neuron RB3 without altering reversal potential of ACh-induced current. Two (sub-) types of cholinoreceptors were distinguished on the basis of findings on OT effects on ACh-induced chloride currents; ACh-induced chloride current was reduced by the action of OT on the cholinoreceptors of one of these (neuron F4) and increased in the case of neurons D5 and F86. The effects of applying OT and serotonin were reversible but not cumulative. Injection of OT exerted an action on ACh-induced chloride current independent of that of OT application. Involvement of cyclic adenosine monophosphate in OT-induced bimodal modulation of functional properties of three types of cholinoreceptors was demonstrated.

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Literature cited

  1. V. A. Dyatlov, "The role of calcium ions in processes modulating serotonin-induced response inHelix pomatia neurons to acetylcholine application," Neirofiziologiya,20, No. 5, 666–671 (1988).

    Google Scholar 

  2. V. A. Dyatlov, "Bimodal action of serotonin on glutamate-induced ionic currents inHelix pomatia neurons," Neirofiziologiya,21, No. 3, 411–413 (1989).

    Google Scholar 

  3. V. A. Dyatlov, Action of serotonin on processes of receptor desensitization induced by gamma-aminobutyric acid in mollusk neurons," Dokl. Akad. Nauk. SSSR,305, No. 1, 238–240 (1989).

    PubMed  Google Scholar 

  4. V. A. Dyatlov, "Cyclic guanosine monophosphate-dependent modulatory effects of serotonin on acetylcholine-induced currents in mollusk neurons," Neirofiziologiya,21, No. 6, 847–850 (1989).

    Google Scholar 

  5. N. I. Kononenko and O. N. Osipenko, "Effects of applying oxytocin toHelix pomatia neurons: depolarizing effects," Neirofiziologiya,20, No. 5, 652–659 (1988).

    Google Scholar 

  6. N. I. Kononenko and O. N. Osipenko, "Effects of applying oxytocin toHelix pomatia neurons: hyperpolarizing effects," Neirofiziologiya,20, No. 5, 659–666 (1988).

    Google Scholar 

  7. T. M. Turpaev, O. P. Yurchenko, and N. G. Grigor'ev, "Changes produced in acetylcholine response in perfused pond snail neurons by serotonin action inside and outside the cell," Neirofiziologiya,18, No. 3, 326–332 (1986).

    Google Scholar 

  8. A. R. Akopyan, N. K. Chemeris, V. I. Iljin, and B. N. Veprintsev, "Serotonin, dopamine and intracellular cyclic AMP inhibit the responses of nicotinic cholinergic membrane in snail neurons," Brain Res.,201, No. 2, 480–484 (1980).

    PubMed  Google Scholar 

  9. D. A. Ausiello, D. H. Kall, and J. M. Dayer, "Modulation of cyclic AMP-dependent protein kinase by vasopressin and calcitonin in cultured porcine renal LLC-PK1 cells," Biochem. J.,186, No. 3, 773–780 (1980).

    PubMed  Google Scholar 

  10. P. J. Boynd, N. N. Osborne, and R. J. Walker, "Localization of arg-vasopressin-like material in central neurones and mechanism of action of arg-vasotocin on identified neurones of the snailHelix aspersa," Neuropharmacology,26, No. 11, 1633–1647 (1987).

    PubMed  Google Scholar 

  11. A. H. Drummond, F. Bucher, and I. B. Levitan, "Distribution of serotonin and dopamine receptors inAplysia tissues: analysis by [3H]-LSD binding and adenylate cyclase stimulation," Brain Res.,148, No. 1, 163–177 (1980).

    Google Scholar 

  12. G. A. Kerkut, J. D. C. Lambert, R. J. Gayton, et al., "Mapping of nerve cells in the suboesophageal ganglia ofHelix aspersa," Comp. Biochem. Physiol., Ser. A.,50, No. 1, 1–25 (1975).

    Google Scholar 

  13. W. Lichtensteiger, D. Felix, and M. Celio, "Effect of alpha-MSH and vasopressin on the giant dopamine neuron ofPlanorbis corneus: modulation of cholinergic-dopaminergic transmission," Adv. Physiol. Sci.,22, No. 2, 495–499 (1980).

    Google Scholar 

  14. H. Steffens, "Cytological aspects of different nerve cell somata in the buccal ganglia ofHelix pomatia L.," Malacologia,18, No. 1/2, 527–532 (1979).

    PubMed  Google Scholar 

  15. O. W. Witte, E.-J. Speckmann, and J. Walden, "Acetylcholine responses of identified neurons inHelix pomatia," Comp. Biochem. Physiol., Ser. C.,80, No. 1, 15–45 (1985).

    Google Scholar 

  16. C. Yagil, B. Frank, and R. Rabkin, "Internalization and catabolism of insulin by an established renal cell line," Am. J. Physiol., Ser. C.,23, No. 6, 822–828 (1988).

    Google Scholar 

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Authors
  1. V. A. Dyatlov
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A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziology, Vol. 22, No. 1, pp. 87–93, January–February, 1990.

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Dyatlov, V.A. Modulatory effects of oxytocin on functional properties of three types of cholinoreceptors in molluskan neurons. Neurophysiology 22, 72–77 (1990). https://doi.org/10.1007/BF01052058

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  • DOI: https://doi.org/10.1007/BF01052058

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