Skip to main content
Log in

The pharmacokinetics of cefixime in the fasted and fed state

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

Twenty healthy adult volunteers received single 400 mg oral doses of cefixime in an open, randomized, crossover study, administered twice in the fasted state and twice with a standard breakfast. The study design allowed both an evaluation of a potential food effect and also an analysis of both intrasubject and intersubject variability in the fasted and fed state.

There was a small but significantly longer (∼1 h) time to peak concentration when the drug was given with food. Peak serum concentrations, area under the curve, and 24 h urinary recovery values were unchanged in the fed and fasted states. The terminal elimination half-life of the drug given after a meal (3.6 h) was slightly longer than that observed after dosing in the fasting condition (3.5 h).

The intrasubject and intersubject variabilities were less than 12% and 33% respectively, for both area under the curve and 24 h urinary recovery, and were virtually the same for the fasted and fed occasions. Therefore, the drug may be administered with or without food.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Falkowski A, Look ZM, Noguchi H, Silber BM (1987) Determination of cefixime in biological samples by reversed phase high performance liquid chromatography. J Chromatogr Biomed Appl 422: 145–152

    Google Scholar 

  2. Gibaldi M, Perrier D (1982) Pharmacokinetics. Marcel Dekker, New York Basel

    Google Scholar 

  3. Riegelman S, Collier P (1980) The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time. J Pharmacokinet Biopharm 8: 509–513

    Google Scholar 

  4. Searle SR, Speed FM, Milliken GA (1980) Populations marginal means in the linear model: An alternative to least squares means. Am Statist 34: 216–221

    Google Scholar 

  5. SAS User's Guide: Statistics (1982) The GLM procedure. SAS Institute Inc, Cary, North Carolina (USA), p 177

    Google Scholar 

  6. Gibaldi M (1984) Biopharmaceutics and clinical pharmacokinetics. Lea and Febiger, Philadelphia, PA

    Google Scholar 

  7. Welling PG (1977) Influence of food and diet on gastrointestinal drug absorption: A review. J Pharmacokinet Biopharm 5: 291–334

    Google Scholar 

  8. Welling PG, Tse FLS (1982) The influence of food on the absorption of antimicrobial agents. J Antimicrob Chemother 9: 7–27

    Google Scholar 

  9. Meyers BR, Kaplan K, Weinstein L (1969) Cephalexin microbiological effects and pharmacologic parameters in man. Clin Pharmacol Ther 10: 810–816

    Google Scholar 

  10. Tetzlaff T, McCracken GH, Thomas ML (1978) Bioavailability of cephalexin and children: Relationship to drug formulations and meals. J Pediatr 92: 292–294

    Google Scholar 

  11. Eschelman FN, Spykev DA (1978) Pharmacokinetics of amoxicillin and ampicillin: Cross-over study of the effect of food. Antimicrob Agents Chemother 14: 539–543

    Google Scholar 

  12. Mischle TW, Sugerman AA, Willard DA, Brannick LJ, Neiss ES (1974) Influence of probenecid and food on the bioavailability of cephradine in normal male subjects. J Clin Pharmacol 14: 604–611

    Google Scholar 

  13. Lode H, Stahlmann R, Koeppe P (1979) Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil and CGP 9000. Antimicrob Agents Chemother 16: 1–6

    Google Scholar 

  14. Ginsburg CM (1982) Comparative pharmacokinetics of cefadroxil, cefaclor, cephalexin and cephradine in infants and children. J Antimicrob Chemother 10 [Suppl b]: 27–31

    Google Scholar 

  15. Harvengt C, de Schepper P, Lamy F, Hansen J (1973) Cephradine absorption and excretion in fasting and nonfasting volunteers. J Clin Pharmacol 13: 36–40

    Google Scholar 

  16. Glynne A, Goulbourn RA, Ryden R (1978) A human pharmacology study of cefaclor. J Antimicrob Chemother 4: 343–348

    Google Scholar 

  17. Williams PEO, Harding SM (1984) The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food. J Antimicrob Chemother 13: 191–196

    Google Scholar 

  18. Yacobi A, Stoll RG, Chao GC, Schwartz RA, Weidler DJ, Ayers JW, Sakmar EA, Hallmark M, Wagner JG (1981) The assessment of the intrasubject variability in digoxin absorption in man from two oral dosage forms. J Clin Pharmacol 21: 301–310

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Faulkner, R.D., Bohaychuk, W., Haynes, J.D. et al. The pharmacokinetics of cefixime in the fasted and fed state. Eur J Clin Pharmacol 34, 525–528 (1988). https://doi.org/10.1007/BF01046715

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01046715

Key words

Navigation